Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome

Autor: Vesna Tomic Spiric, Bojan Petrovic, Dejan Markovic, Aleksandra Peric Popadic, Vesna Radojević, Biljana Andjelski Radicevic, Radmila Jančić Heinemann, Tamara Peric, Tatjana Todorovic, Gordana Susic
Rok vydání: 2015
Předmět:
Male
Dental plaque
Saliva
Dentistry
chemistry.chemical_compound
Casein
Materials Testing
polycyclic compounds
Longitudinal Studies
Enamel remineralisation
Enamel paint
Chemistry
Caseins
Hydrogen-Ion Concentration
Middle Aged
Treatment Outcome
Sjogren's syndrome
visual_art
visual_art.visual_art_medium
Female
Salivation
Serbia
psychological phenomena and processes
Adult
Adolescent
Casein phosphopeptide-amorphous calcium fluoride phosphate
Surface Properties
chemistry.chemical_element
Calcium
stomatognathic system
medicine
Humans
General Dentistry
Aged
Remineralisation
business.industry
Spectrometry
X-Ray Emission
Tooth surface
medicine.disease
Phosphate
body regions
Calcium Fluoride
Casein phosphopeptide-amorphous calcium phosphate
Tooth Remineralization
Dentin
Microscopy
Electron
Scanning
Sodium Fluoride
business
Zdroj: Clinical Oral Investigations
Popis: The purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjogren’s syndrome (SS). Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects. At the end of the experimental period, a slight increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects’ dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups. CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS. Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS.
Databáze: OpenAIRE
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