Recognition and management of common, rare, and novel serum protein electrophoresis and immunofixation interferences
| Autor: | Hélène Caillon, Joannes F M Jacobs, David F. Keren, Thomas Dejoie, Kristian Thidemann Andersen, Christopher R. McCudden |
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| Rok vydání: | 2018 |
| Předmět: |
Immunofixation
Antifungal Agents Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] Contrast dye Clinical Biochemistry Contrast Media Context (language use) Review Computational biology 030204 cardiovascular system & hematology Blood Proteins/analysis Hemolysis Antibodies 03 medical and health sciences 0302 clinical medicine Blood Protein Electrophoresis/methods Antibiotics Hydroxocobalamin Journal Article medicine Animals Humans Monoclonal therapy IgG4 biology medicine.diagnostic_test Serum protein electrophoresis Chemistry Fibrinogen Antibodies/blood Blood Proteins General Medicine Blood Protein Electrophoresis Anti-Bacterial Agents Interferences 030220 oncology & carcinogenesis Immunology biology.protein Monoclonal protein Artifacts |
| Zdroj: | Clinical Biochemistry, 51, 72-79 Clinical Biochemistry, 51, pp. 72-79 McCudden, C R, Jacobs, J F M, Keren, D, Caillon, H, Dejoie, T & Andersen, K 2018, ' Recognition and management of common, rare, and novel serum protein electrophoresis and immunofixation interferences ', Clinical Biochemistry, vol. 51, pp. 72-79 . https://doi.org/10.1016/j.clinbiochem.2017.08.013 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/j.clinbiochem.2017.08.013 |
| Popis: | Item does not contain fulltext Protein electrophoresis and immunofixation are subject to a variety of analytical interferences that may affect monoclonal protein diagnostics performed in the context of monoclonal gammopathies. Interferences include endogenous substances, such as hemoglobin and fibrinogen, and exogenous compounds, such as radiocontrast dyes, antibiotics, and monoclonal antibody therapies. General approaches to managing interferences begin with recognition of the problem. Provided herein are examples of common, rare, and novel interferences with the goal of providing a comprehensive overview. With each example, specific methods and strategies are provided to manage analytical interferences to ensure that interpretative reports are accurate. Longstanding and newer technologies are also described to contextualize where interferences may be identified and avoided. |
| Databáze: | OpenAIRE |
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