Assisted reproductive technology outcomes in azoospermic men: 10 years of experience with surgical sperm retrieval

Autor:	Daniela Paes de Almeida Ferreira Braga, Luciana Semião-Francisco, Edson Borges, Figueira Rde C, Fabio F. Pasqualotto, Camila Madaschi, Assumpto Iaconelli
Rok vydání:	2010
Předmět:	Adult Male medicine.medical_specialty Sperm Retrieval medicine.medical_treatment Obstructive azoospermia Andrology Human fertilization Pregnancy medicine Humans Sperm Injections Intracytoplasmic reproductive and urinary physiology Azoospermia Gynecology Assisted reproductive technology urogenital system business.industry Pregnancy Outcome Middle Aged medicine.disease Spermatozoa Sperm Fertilization Female Geriatrics and Gerontology business Spermatogenesis
Zdroj:	The Aging Male. 13:44-50
ISSN:	1473-0790 1368-5538
DOI:	10.3109/13685530903342203
Popis:	An azoospermic man suffers from an absence of sperm in the ejaculate and this condition is present in about 10% of infertile men. Obstructive azoospermia (OA) is characterized by an occlusion or partial absence of the reproductive tract with the presence of normal spermatogenesis. On the other hand, non-obstructive azoospermia (NOA) is characterized by impaired spermatogenesis. In these cases, spermatozoa can be obtained by percutaneous epididymal or testicular sperm aspiration (PESA and TESA, respectively) and used for intracytoplasmic injection (ICSI). To compare ICSI outcomes using spermatozoa that were surgically retrieved by PESA and TESA, azoospermic patients were divided into the following categories: (i) TESA-NOA (n = 102), (ii) TESA-OA (n = 103), and (iii) PESA-OA (n = 171). Fertilization, pregnancy, and implantation rates were compared between the groups. We noted a lower normal fertilization rate (p = 0.0017) and a higher abortion rate (p = 0.0387) among men in the TESA group who had OA when compared with men in the PESA group who had OA. On the other hand, a lower normal fertilization rate (p = 0.05) and a lower rate of non-cleaved embryos (p = 0.034) was found in the TESA group of NOA patients as compared to the TESA group of OA patients. No statistically significant differences were detected between the TESA and PESA groups and the OA and NOA groups, respectively. The clinical outcomes of embryos arising from ICSI cycles using spermatozoa harvested via PESA and TESA were similar, regardless of whether the patient had obstructive or non-obstructive azoospermia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00da2270ce9eec07db9259acd39d2c6f https://doi.org/10.3109/13685530903342203 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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