The protective effects of silibinin in the treatment of streptozotocin-induced diabetic osteoporosis in rats
| Autor: | Xiaozhou Ying, Qingqing Wang, Leyi Cai, Yangyang Wang, Te Wang, Di Lu, Hua Chen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant medicine.medical_treatment Osteoporosis Silibinin Protective Agents medicine.disease_cause Diabetes Mellitus Experimental 03 medical and health sciences chemistry.chemical_compound Bone Density Osteogenesis Trabecular Meshwork Internal medicine Diabetes mellitus medicine Animals Femur Rats Wistar Pharmacology Bone mineral Bone Density Conservation Agents business.industry Anti-Inflammatory Agents Non-Steroidal General Medicine medicine.disease Streptozotocin Rats Oxidative Stress 030104 developmental biology Endocrinology chemistry Silybin Female business Complication Oxidative stress Silymarin medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy. 89:681-688 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2017.02.018 |
| Popis: | Diabetic osteoporosis (DO) is a complication of diabetes mellitus. Our previous study showed that silibinin can attenuate high glucose mediated human bone marrow stem cells dysfunction through antioxidant effect. However, no study has yet investigated the effect of silibinin in diabetic rats. Therefore, we assessed the effects of silibinin on bone characteristics in streptozotocin-induced diabetic rats. The aim of our study was to determine whether providing silibinin in the different supplementation could prevent bone loss in diabetic rats or not. Rats were randomly divided into four groups: (1) control group (CG) (n=10); (2) diabetic group (DG) (n=10); (3) diabetic group with 50mgkg-1day-1 of silibinin orally (DG-50) (n=10); and (4) diabetic group with 100mgkg-1day-1 of silibinin orally (DG-100) (n=10). 12 weeks after streptozotocin (STZ) injection, the femora from all rats were assessed and oxidative stress was evaluated. Bone mineral density was significantly decreased in diabetic rats; these effects were prevented by treatment with silibinin (100mgkg-1day-1 orally). Similarly, in the DG and DG-50 groups, changes in microarchitecture of femoral metaphysis assessed by microcomputed tomography demonstrated simultaneous existence of diabetic osteoporosis; these impairments were prevented by silibinin (100mgkg-1day-1 orally). In conclusion, silibinin supplementation may have potential use as a possible therapy for maintaining skeletal health and these results can enhance the understanding of diabetic osteoporosis induced by diabetes. |
| Databáze: | OpenAIRE |
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