Bone turnover, calcium homeostasis, and vitamin D status in Danish vegans

Autor: Oluf Pedersen, Arieh Cohen, Henrik Vestergaard, Torben Hansen, Tue H. Hansen, Kristine H. Allin, Marie Madsen, Niklas Rye Jørgensen
Rok vydání: 2017
Předmět:
0301 basic medicine
Procollagen/blood
Male
Bone density
Peptides/blood
Denmark
Medicine (miscellaneous)
Parathyroid hormone
Bone remodeling
0302 clinical medicine
Blood serum
Calcium
Dietary/administration & dosage
Vitamin D
Nutrition and Dietetics
biology
Osteocalcin/blood
Vitamin D/administration & dosage
Bone Remodeling/physiology
Parathyroid Hormone
Osteocalcin
Female
Bone Remodeling
Procollagen
Adult
medicine.medical_specialty
Diet
Vegan
Collagen Type I/blood
Nutritional Status
030209 endocrinology & metabolism
Calcium/administration & dosage
Bone and Bones
Collagen Type I
03 medical and health sciences
Young Adult
N-terminal telopeptide
Internal medicine
medicine
Vitamin D and neurology
Humans
Calcium metabolism
Vegans
030109 nutrition & dietetics
business.industry
Feeding Behavior
Alkaline Phosphatase
Peptide Fragments
Calcium
Dietary
Endocrinology
Parathyroid Hormone/blood
biology.protein
Calcium
business
Alkaline Phosphatase/blood
Peptide Fragments/blood
Peptides
Zdroj: Hansen, T H, Madsen, M T B, Jørgensen, N R, Cohen, A S, Hansen, T, Vestergaard, H, Pedersen, O & Allin, K H 2018, ' Bone turnover, calcium homeostasis, and vitamin D status in Danish vegans ', European Journal of Clinical Nutrition, vol. 72, no. 7, pp. 1046–1054 . https://doi.org/10.1038/s41430-017-0081-y
ISSN: 1476-5640
DOI: 10.1038/s41430-017-0081-y
Popis: Background/objectives: A vegan diet has been associated with increased bone fracture risk, but the physiology linking nutritional exposure to bone metabolism has only been partially elucidated. This study investigated whether a vegan diet is associated with increased bone turnover and altered calcium homeostasis due to insufficient intake of calcium and vitamin D. Subjects/methods: Fractionated and total 25-hydroxyvitamin D (25(OH)-D), parathyroid hormone (PTH), calcium, and four bone turnover markers (osteocalcin, N-terminal propeptide of type I procollagen (PINP), bone-specific alkaline phosphatase (BAP), and C-terminal telopeptide of type I collagen (CTX)) were measured in serum from 78 vegans and 77 omnivores. Results: When adjusting for seasonality and constitutional covariates (age, sex, and body fat percentage) vegans had higher concentrations of PINP (32 [95% CI: 7, 64]%, P = 0.01) and BAP (58 [95% CI: 27, 97]%, P < 0.001) compared to omnivores, whereas CTX (30 [95% CI: -1, 72]%, P = 0.06) and osteocalcin (21.8 [95% CI: -9.3, 63.7]%, P = 0.2) concentrations did not differ between the two groups. Vegans had higher serum PTH concentration (38 [95% CI: 19, 60]%; P < 0.001) and lower 25(OH)-D serum concentration (-33 [95% CI: -45, -19]%; P < 0.001), but similar serum calcium concentration (-1 [95% CI: -3, 1]%, P = 0.18 compared to omnivores. Conclusions: Vegans have higher levels of circulating bone turnover markers compared to omnivores, which may in the long-term lead to poorer bone health. Differences in dietary habits including intake of vitamin D and calcium may, at least partly, explain the observed differences.
Databáze: OpenAIRE
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