Flavonoids with gastroprotective activity
Autor: | Leônia Maria Batista, Guilherme Eduardo Nunes Dias, Ânderson Luiz-Ferreira, Meri Emili F. Pinto, Alba Regina Monteiro Souza-Brito, Kelly Samara de Lira Mota, Clélia Akiko Hiruma-Lima, José Maria Barbosa-Filho |
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Přispěvatelé: | Universidade Federal da Paraíba (UFPB), Universidade Estadual de Campinas (UNICAMP), Universidade Estadual Paulista (Unesp) |
Jazyk: | angličtina |
Rok vydání: | 2009 |
Předmět: |
medicine.medical_specialty
Peptic Ulcer Peptic phenol derivative Flavonoid review Pharmaceutical Science Disease Review Pharmacology Protective Agents Gastroenterology Analytical Chemistry Peptic ulcers lcsh:QD241-441 lcsh:Organic chemistry Phenols Internal medicine Natural products Drug Discovery Effective treatment Medicine Humans flavonoid human Physical and Theoretical Chemistry Available drugs Gastroprotective activity polyphenols protective agent chemistry.chemical_classification Flavonoids business.industry Stomach Organic Chemistry food and beverages Polyphenols digestive system diseases medicine.anatomical_structure chemistry Chemistry (miscellaneous) Molecular Medicine business Proximal duodenum |
Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Molecules Molecules, Vol 14, Iss 3, Pp 979-1012 (2009) |
Popis: | Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:23:52Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:46:25Z : No. of bitstreams: 1 2-s2.0-63449104070.pdf: 377118 bytes, checksum: 5efaadc41eb141b5f21f6a1cf099e5ef (MD5) Made available in DSpace on 2014-05-27T11:23:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-03-01 Peptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. The use of natural products for the prevention and treatment of different pathologies is continuously expanding throughout the world. This is particularly true with regards to flavonoids, which represent a highly diverse class of secondary metabolites with potentially beneficial human health effects that is widely distributed in the plant kingdom and currently consumed in large amounts in the diet. They display several pharmacological properties in the gastroprotective area, acting as anti-secretory, cytoprotective and antioxidant agents. Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers and additionally these polyphenolic compounds can be new alternatives for suppression or modulation of peptic ulcers associated with H. pylori. In this review, we have summarized the literature on ninety-five flavonoids with varying degrees of antiulcerogenic activity, confirming that flavonoids have a therapeutic potential for the more effective treatment of peptic ulcers. Laboratório de Tecnologia Farmacêutica Prof. Delby Fernandes de Medeiros - LTF Universidade Federal da Paraíba - UFPB, Cx. Postal 5009, 58051-970, João Pessoa, PB Laboratório de Produtos Naturais Universidade Estadual de Campinas - UNICAMP, Cx. Postal 6109, 13083-970, Campinas, SP Departamento de Fisiologia Instituto de Biosciência Universidade Estadual de São Paulo-UNESP, c.p. 510, Zip Code: 18618-000, Botucatu, SP Departamento de Fisiologia Instituto de Biosciência Universidade Estadual de São Paulo-UNESP, c.p. 510, Zip Code: 18618-000, Botucatu, SP |
Databáze: | OpenAIRE |
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