Short- and long-term risk of colorectal adenoma recurrence among whites and blacks
| Autor: | Hassan Ashktorab, Elaine Lanza, Adeyinka O. Laiyemo, Aline Charabaty, Samir Gupta, Chyke A. Doubeni, Robert E. Schoen, Duane T. Smoot, Hassan Brim, Amanda J. Cross, Elizabeth A. Platz |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty Colonoscopy Colorectal adenoma Statistics Nonparametric White People Article Internal medicine Confidence Intervals Humans Medicine Radiology Nuclear Medicine and imaging Aged Chi-Square Distribution medicine.diagnostic_test business.industry Incidence Incidence (epidemiology) Gastroenterology Middle Aged medicine.disease Non-Hispanic whites United States digestive system diseases Surgery Black or African American Relative risk Female Polyp Prevention Trial Neoplasm Recurrence Local Colorectal Neoplasms business Chi-squared distribution |
| Zdroj: | Gastrointestinal Endoscopy. 77:447-454 |
| ISSN: | 0016-5107 |
| DOI: | 10.1016/j.gie.2012.11.027 |
| Popis: | Background It is unclear whether the higher burden from colorectal cancer among blacks is due to an increased biological susceptibility. Objective To determine whether non-Hispanic blacks (blacks) have a higher risk of adenoma recurrence than non-Hispanic whites (whites) after removal of colorectal adenoma. Design Secondary analysis of the Polyp Prevention Trial (PPT) data. Setting United States. Patients Patients were 1668 self-identified whites and 153 blacks who completed the 4-year trial. Of these, 688 whites and 55 blacks enrolled in a posttrial, passive Polyp Prevention Trial Continued Follow-up Study (PPT-CFS) and underwent another colonoscopy. Main Outcome Measurements Recurrence and location of the adenoma and advanced adenoma by race-ethnicity during PPT and cumulative recurrence over a mean follow-up of 8.3 years (range, 4.9-12.4 years) among PPT-CFS enrollees. Results Blacks had similar risk of recurrence of adenoma (39.2% vs 39.4%; incidence risk ratio [RR] = .98; 95% CI, .80-1.20) and advanced adenoma (8.5% vs 6.4%; RR=1.18; 95% CI, .68-2.05) as whites at the end of PPT. Recurrence risk did not differ by colon subsite. Among PPT-CFS enrollees, the cumulative recurrence rate over a maximal follow-up period of 12 years was similar for blacks and whites for adenoma (67.3% vs 67.0%; RR=1.01; 95% CI, .84-1.21) and advanced adenoma (14.5% vs 16.9%; RR=1.03; 95% CI, .60-1.79). Limitation There were few blacks in the long-term follow-up study. Conclusions Adenoma and advanced adenoma recurrence did not differ by race. Our study does not support more frequent surveillance colonoscopies for blacks with a personal history of adenoma as an intervention to reduce colorectal cancer disparity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect