Pediatric gastritis and its impact on hematologic parameters
| Autor: | Maria Oana Săsăran, Ecaterina Daniela Dobru, Lorena Elena Meliţ, Simona Mocan, Dana Valentina Ghiga |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty hematologic parameters Adolescent Lymphocyte Observational Study Hematocrit Gastroenterology Helicobacter Infections 03 medical and health sciences 0302 clinical medicine children Internal medicine Humans Medicine Lymphocyte Count Prospective Studies 030212 general & internal medicine Mean platelet volume Child Prospective cohort study Helicobacter pylori medicine.diagnostic_test biology business.industry gastritis Case-control study Complete blood count General Medicine biology.organism_classification medicine.anatomical_structure Case-Control Studies 030220 oncology & carcinogenesis Female Gastritis medicine.symptom business Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000021985 |
| Popis: | Non-invasive biomarkers, such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, may predict inflammation in various disorders, including gastritis, according to recent data. Nevertheless, various studies reported an association between Helicobacter pylori (H pylori) and immune thrombocytopenia in both adults and pediatric patients. The objective of our study was to evaluate the impact of pediatric gastritis, caused or not by H pylori infection on erythrocytes, their parameters, thrombocytes, mean platelet volume, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). We performed a prospective, case–control study on 151 patients aged between 1 and 17 years who presented with chronic dyspeptic symptoms. An upper digestive endoscopy with gastric biopsies and a complete blood count was performed in each case. Control group consisted of 67 patients with normal histological findings, while the two study groups were divided into group 1—H pylori-induced gastritis (31 patients) and group 2—non-H pylori-induced gastritis (53 patients). Children from the rural area were more likely to develop both types of gastritis (P .05). However, significantly higher values of lymphocytes were associated with non-H pylori-induced gastritis (P |
| Databáze: | OpenAIRE |
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