Clinical Trial of Low-Fat, High-Carbohydrate Diet in Subjects With Mammographic Dysplasia: Report of Early Outcomes
| Autor: | Wedad Hanna, Edward B. Fish, David L. Page, Eve Fishell, Valentina Kriukov, Gina Lockwood, Mary Beaton, Barbara Wright, Norman F. Boyd, David Tritchler, Mary Cousins |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Calorie Randomization Breast Neoplasms law.invention Breast cancer Randomized controlled trial law Internal medicine Dietary Carbohydrates Humans Medicine Mammography Risk factor Fibrocystic Breast Disease medicine.diagnostic_test business.industry Body Weight medicine.disease Dietary Fats Surgery Clinical trial Cholesterol Oncology Dysplasia Female business |
| Zdroj: | JNCI Journal of the National Cancer Institute. 80:1244-1248 |
| ISSN: | 1460-2105 0027-8874 |
| DOI: | 10.1093/jnci/80.15.1244 |
| Popis: | Despite evidence that dietary fat intake may influence breast cancer risk, there is little information about the effects of dietary fat on the human breast. We have studied the effects of dietary fat on the breast by examining the influence of dietary fat reduction on mammographic dysplasia (nodular or sheetlike areas of radiological density). Subjects with mammographic dysplasia were randomly allocated to a control group, in which they received advice about maintaining a balanced diet (36% of calories as fat), or an intervention group, in which they were taught to reduce dietary fat to a target of 15% of calories. A total of 295 patients consented to randomization, and after 1 year, 20% of the intervention group and 5% of the control group had dropped out (failed to keep appointments and provide nutrient data). The remaining patients closely adhered to the dietary goals of the study as assessed by food records, chemical analysis of duplicate meals, and serum cholesterol measurements. Comparison of mammograms before and after 1 year of dietary fat reduction shows no significant influence on the extent or density of mammographic dysplasia. Surgical biopsies performed in subjects after entry in the study showed five cancers in the control group and two cancers in the intervention group; this total of seven cancers is four times the number expected. These data show that clinical trials of the effects of dietary fat reduction on breast cancer risk are feasible and that long-term compliance with a low-fat diet can be achieved, and they confirm that the patients selected because they had mammographic dysplasia had increased risk of breast cancer. |
| Databáze: | OpenAIRE |
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