Allergenicity of bony and cartilaginous fish - molecular and immunological properties
| Autor: | Juan N. Stephen, Aya C Taki, Thimo Ruethers, Michael F. Sharp, Andreas L. Lopata, Dianne E. Campbell |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Muscle tissue Allergy Immunology Zoology Cross Reactions medicine.disease_cause 03 medical and health sciences Epitopes 0302 clinical medicine Allergen medicine Immunology and Allergy Animals Humans Carp Coelacanth biology Ecology Fishes Environmental exposure Environmental Exposure Allergens Immunoglobulin E biology.organism_classification medicine.disease Chondrichthyes 030104 developmental biology medicine.anatomical_structure 030228 respiratory system biology.protein Parvalbumin Food Hypersensitivity |
| Zdroj: | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 47(3) |
| ISSN: | 1365-2222 |
| Popis: | Allergy to bony fish is common and probably increasing world-wide. The major heat-stable pan-fish allergen, parvalbumin (PV), has been identified and characterized for numerous fish species. In contrast, there are very few reports of allergic reactions to cartilaginous fish despite widespread consumption. The molecular basis for this seemingly low clinical cross-reactivity between these two fish groups has not been elucidated. PV consists of two distinct protein lineages, α and β. The α-lineage of this protein is predominant in muscle tissue of cartilaginous fish (Chondrichthyes), while β-PV is abundant in muscle tissue of bony fish (Osteichthyes). The low incidence of allergic reactions to ingested rays and sharks is likely due to the lack of molecular similarity, resulting in reduced immunological cross-reactivity between the two PV lineages. Structurally and physiologically, both protein lineages are very similar; however, the amino acid homology is very low with 47-54%. Furthermore, PV from ancient fish species such as the coelacanth demonstrates 62% sequence homology to leopard shark α-PV and 70% to carp β-PV. This indicates the extent of conservation of the PV isoforms lineages across millennia. This review highlights prevalence data on fish allergy and sensitization to fish, and details the molecular diversity of the two protein lineages of the major fish allergen PV among different fish groups, emphasizing the immunological and clinical differences in allergenicity. |
| Databáze: | OpenAIRE |
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