Gold(iii) chloride catalysed synthesis of 5-alkylidene-dihydrothiazoles

Autor:	Leander P. D. Vervaecke, Thomas S. A. Heugebaert, Christian V. Stevens
Rok vydání:	2011
Předmět:	Alkylation Molecular Structure Chemistry Organic Chemistry Two step Ring (chemistry) Biochemistry Combinatorial chemistry Catalysis Gold Compounds Gold(III) chloride Thiazoles chemistry.chemical_compound Organic chemistry Hydrogenation Physical and Theoretical Chemistry
Zdroj:	Organic & Biomolecular Chemistry. 9:4791
ISSN:	1477-0539 1477-0520
DOI:	10.1039/c1ob05509g
Popis:	A two step synthesis of dihydrothiazoles is presented. First, the previously unknown N-propargylic dithiocarboimidates are produced in good yields from easily available, cheap starting materials. The subsequent gold catalysed ring closure is fast and efficient, leading to dihydrothiazoles through a cascade of 5-exo-dig cyclisation and 1,3-alkyl migration. The yields range from 74% to 95%.
Databáze:	OpenAIRE
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