Efficient Assembly of Threaded Molecular Machines for Sequence-Specific Synthesis
| Autor: | Marcus Papmeyer, Bartosz Lewandowski, John W. Ward, David A. Leigh, Guillaume De Bo, Sonja Kuschel |
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| Rok vydání: | 2014 |
| Předmět: |
Rotaxane
Rotaxanes Chemistry Synthon Sequence (biology) Nanotechnology General Chemistry Parallel computing Native chemical ligation Ring (chemistry) Peptide Mapping Biochemistry Oligomer Catalysis Molecular machine chemistry.chemical_compound Colloid and Surface Chemistry Tandem Mass Spectrometry Amino Acid Sequence |
| Zdroj: | De Bo, G, Kuschel, S, Leigh, D A, Lewandowski, B, Papmeyer, M & Ward, J W 2014, ' Efficient assembly of threaded molecular machines for sequence-specific synthesis ', Journal of the American Chemical Society, vol. 136, no. 15, pp. 5811-5814 . https://doi.org/10.1021/ja5022415 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja5022415 |
| Popis: | We report on an improved strategy for the preparation of artificial molecular machines that can pick up and assemble reactive groups in sequence by traveling along a track. In the new approach a preformed rotaxane synthon is attached to the end of an otherwise fully formed strand of building blocks. This "rotaxane-capping" protocol is significantly more efficient than the "final-step-threading" method employed previously and enables the synthesis of threaded molecular machines that operate on extended oligomer, and potentially polymer, tracks. The methodology is exemplified through the preparation of a machine that adds four amino acid building blocks from a strand in sequence, featuring up to 20-membered ring native chemical ligation transition states. © 2014 American Chemical Society. |
| Databáze: | OpenAIRE |
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