A comparison of phenotype definitions for diabetes mellitus
| Autor: | Mark N. Feinglos, Bryan C. Batch, Douglas Wixted, Susan E. Spratt, Marie Lynn Miranda, Shelley A. Rusincovitch, Robert M. Califf, W. Ed Hammond, Rachel L. Richesson |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Gerontology medicine.medical_specialty Concordance Population Health Informatics Research and Applications International Classification of Diseases Diabetes mellitus Health care Diabetes Mellitus Electronic Health Records Humans Medicine education education.field_of_study business.industry Medical record Mean age Middle Aged medicine.disease Phenotype Clinical research Family medicine Female business Algorithms |
| Zdroj: | Journal of the American Medical Informatics Association. 20:e319-e326 |
| ISSN: | 1527-974X 1067-5027 |
| DOI: | 10.1136/amiajnl-2013-001952 |
| Popis: | Objective This study compares the yield and characteristics of diabetes cohorts identified using heterogeneous phenotype definitions. Materials and methods Inclusion criteria from seven diabetes phenotype definitions were translated into query algorithms and applied to a population (n=173 503) of adult patients from Duke University Health System. The numbers of patients meeting criteria for each definition and component (diagnosis, diabetes-associated medications, and laboratory results) were compared. Results Three phenotype definitions based heavily on ICD-9-CM codes identified 9–11% of the patient population. A broad definition for the Durham Diabetes Coalition included additional criteria and identified 13%. The electronic medical records and genomics, NYC A1c Registry, and diabetes-associated medications definitions, which have restricted or no ICD-9-CM criteria, identified the smallest proportions of patients (7%). The demographic characteristics for all seven phenotype definitions were similar (56–57% women, mean age range 56–57 years).The NYC A1c Registry definition had higher average patient encounters (54) than the other definitions (range 44–48) and the reference population (20) over the 5-year observation period. The concordance between populations returned by different phenotype definitions ranged from 50 to 86%. Overall, more patients met ICD-9-CM and laboratory criteria than medication criteria, but the number of patients that met abnormal laboratory criteria exclusively was greater than the numbers meeting diagnostic or medication data exclusively. Discussion Differences across phenotype definitions can potentially affect their application in healthcare organizations and the subsequent interpretation of data. Conclusions Further research focused on defining the clinical characteristics of standard diabetes cohorts is important to identify appropriate phenotype definitions for health, policy, and research. |
| Databáze: | OpenAIRE |
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