Preservation of anthocyanins in solid lipid nanoparticles: Optimization of a microemulsion dilution method using the Placket–Burman and Box–Behnken designs
| Autor: | Raheleh Ravanfar, Ali Mohammad Tamaddon, Mehrdad Niakousari, Mahmoud Reza Moein |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Brassica Analytical Chemistry Anthocyanins 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology food Phenols Solid lipid nanoparticle Microemulsion Particle Size 030109 nutrition & dietetics Chromatography Red cabbage Chemistry Aqueous two-phase system Water food and beverages 04 agricultural and veterinary sciences General Medicine Lipids 040401 food science Box–Behnken design food.food Dilution Microscopy Electron Scanning Nanoparticles Digestion Emulsions Particle size Food Science |
| Zdroj: | Food Chemistry. 199:573-580 |
| ISSN: | 0308-8146 |
| DOI: | 10.1016/j.foodchem.2015.12.061 |
| Popis: | Anthocyanins are the main polyphenol components from red cabbage (Brassica oleracea L. Var. Capitata f. Rubra) extracts that have inherent antioxidant activities. Anthocyanins are effectively stable in acidic gastric digestion conditions, with nearly 100% phenol content recovery. However, the total phenol content recovery after simulated pancreatic digestion was approximately 25%. To protect anthocyanins against harsh environmental conditions (e.g., pH and temperature), solid lipid nanoparticles were prepared by the dilution of water in oil (w/o) microemulsions containing anthocyanins in aqueous media. The formulations were characterized for particle size and encapsulation efficiency. The formulation parameters (e.g., volume of the internal aqueous phase, homogenization time and the percentages of total lipid, total surfactant or stabilizer) were optimized using the Placket-Burman and Box-Behnken experimental designs. Entrapment efficiency (89.2 ± 0.3%) was calculated when the mean particle size was 455 ± 2 nm. A scanning electron microscopy study revealed the spherical morphology of the particles. |
| Databáze: | OpenAIRE |
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