Studies on the replication of Mayaro virus grown in interferon treated cells
| Autor: | Maria Evangelina Ferreira Fonseca, M. A. Rebello, J. O. Marinho, M. C. S. Rebello |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Microbiology (medical)
Aedes albopictus lcsh:Arctic medicine. Tropical medicine Mayaro virus replication lcsh:RC955-962 viruses Population lcsh:QR1-502 Alphavirus Biology Interferon alpha-2 Virus Replication Virus lcsh:Microbiology law.invention Viral Proteins Interferon law Aedes medicine Animals education Host protein education.field_of_study Budding Interferon-alpha interferon biology.organism_classification Virology Recombinant Proteins Electrophoresis Polyacrylamide Gel Electron microscope medicine.drug |
| Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 89, Iss 4, Pp 619-623 (1994) Memórias do Instituto Oswaldo Cruz, Volume: 89, Issue: 4, Pages: 619-623, Published: DEC 1994 |
| ISSN: | 1678-8060 0074-0276 |
| Popis: | Mayaro virus grown in interferon treated infected cells has been characterized with regard to its ability to replicate in vertebrate (TC7) and invertebrate (Aedes albopictus) cells. Virus purified from interferon treated TC7 cells adsorbs and penetrates to the same extent as the control virus. During infection, these virus particles caused inhibition of host protein synthesis and synthesized the same spectrum of viral proteins as normal virus. This population however, was apparently more sensitive to interferon treatment. Electron microscopy of TC7 cells showed the presence of numerous aberrant virus particles budding from the plasma membrane. |
| Databáze: | OpenAIRE |
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