Effect of SARS-CoV-2 Infection in Pregnancy on Maternal and Neonatal Outcomes in Africa: An AFREhealth Call for Evidence through Multicountry Research Collaboration
| Autor: | Alimuddin Zumla, Nancy Mwongeli, Eduard J Mills, Onesmus Gachuno, Mukanire Ntakwinja, Jean B. Nachega, Don Jethro Mavungu Landu, Christian Bongo-Pasi Nswe, Jean-Jacques Muyembe Tamfum, Emily R. Smith, Samantha Budhram, John Ditekemena, Philippa Musoke, John O Otshudiema, Denis Mukwege, Jean-Marie Ntumba Kayembe, Lawal Waisu Umar, Priya Soma-Pillay, Nadia A. Sam-Agudu, Michel Tshiasuma Pipo, Daniel Katuashi Ishoso, Rhoderick Machekano, Taha E. Taha, Eduard Langenegger, Musa Sekikubo, John Kinuthia, Valerie Vannevel, Placide Mbala-Kingebeni, Birhanu Teshome Ayele, Evans Kofi Agbeno, Lynne M. Mofenson |
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| Rok vydání: | 2020 |
| Předmět: |
Tuberculosis
030231 tropical medicine Population MEDLINE Context (language use) Perspective Piece 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Virology Environmental health Humans Medicine Prospective Studies Pregnancy Complications Infectious Prospective cohort study education Intersectoral Collaboration Africa South of the Sahara Retrospective Studies education.field_of_study Coinfection SARS-CoV-2 business.industry Transmission (medicine) Research Infant Newborn COVID-19 medicine.disease Infectious Disease Transmission Vertical Infectious Diseases Socioeconomic Factors Premature Birth Female Parasitology Pregnant Women business Malaria |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.20-1553 |
| Popis: | In the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), it is important to evaluate coinfections with SARS-CoV-2 and their impact on maternal/infant outcomes. Robust research is critically needed to evaluate the effects of the added burden of COVID-19 in pregnancy, to help develop evidence-based policies toward improving maternal and infant outcomes. In this perspective, we briefly review current knowledge on the clinical features of COVID-19 in pregnancy; the risks of preterm birth and cesarean delivery secondary to comorbid severity; the effects of maternal SARS-CoV-2 infection on the fetus/neonate; and in utero mother-to-child SARS-CoV-2 transmission. We further highlight the need to conduct multicountry surveillance as well as retrospective and prospective cohort studies across SSA. This will enable assessments of SARS-CoV-2 burden among pregnant African women and improve the understanding of the spectrum of COVID-19 manifestations in this population, which may be living with or without HIV, TB, and/or other coinfections/comorbidities. In addition, multicountry studies will allow a better understanding of risk factors and outcomes to be compared across countries and subregions. Such an approach will encourage and strengthen much-needed intra-African, south-to-south multidisciplinary and interprofessional research collaborations. The African Forum for Research and Education in Health’s COVID-19 Research Working Group has embarked upon such a collaboration across Western, Central, Eastern and Southern Africa. |
| Databáze: | OpenAIRE |
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