Brain MRI in late-onset multiple sclerosis
| Autor: | T. Stojkovic, Luc Defebvre, Jean-Yves Gauvrit, M A Mackowiak, Patrick Vermersch, J. de Seze, S. Delalande, E. Michelin, Didier Ferriby, J P Pruvo |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Pathology medicine.medical_specialty Multiple Sclerosis Late onset Sensitivity and Specificity Cerebrospinal fluid Reference Values medicine Brain mri Humans In patient Prospective Studies Prospective cohort study Aged Observer Variation medicine.diagnostic_test business.industry Multiple sclerosis Brain Reproducibility of Results Magnetic resonance imaging McDonald criteria Middle Aged medicine.disease Magnetic Resonance Imaging Neurology Evaluation Studies as Topic Case-Control Studies Female Neurology (clinical) Nuclear medicine business Follow-Up Studies |
| Zdroj: | ResearcherID |
| ISSN: | 1468-1331 1351-5101 |
| Popis: | Multiple sclerosis (MS) with clinical onset after 50 years of age is unusual (between 1 and 6%) and is frequently misdiagnosed. Furthermore, brain magnetic resonance imaging (MRI) abnormalities are frequently observed in subjects over 50 years of age. The aim of this study was to describe brain MRI in late-onset MS to evaluate the sensitivity and specificity of radiological MS criteria in patients aged over 50 years. We evaluated the brain MRI of 20 patients with onset of MS after 50 years of age. We compared these MRI with 26 controls matched for age, sex and vascular risk factors. MRI were blindly analysed by two neuroradiologists according to Paty et al.'s [Neurology38 (1988) 180] criteria, Fazekas et al.'s [Neurology38 (1988) 1822] criteria and Barkhof et al.'s [Brain120 (1997) 2059] criteria. The mean age at MRI scanning was 58 years. Sensitivity was 90% for Paty et al.'s criteria, 80% for Fazekas et al.'s criteria and 85% for Barkhof et al.'s criteria. Specificity was 54% for Paty et al.'s criteria, 69% for Fazekas et al.'s criteria and 65% for Barkhof et al.'s criteria. Barkhof et al.'s criteria are less specific in older patients than in young patients. We suggest that spinal cord MRI and cerebrospinal fluid analysis should be systematically performed in suspected late-onset MS in order to increase the specificity of the diagnosis. |
| Databáze: | OpenAIRE |
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