N-carbamoyl analogs of zafirlukast: Potent receptor antagonists of leukotriene D4

Autor:	Molly A. McGlynn, Matthew Frank Brown, Stacie P. O'Sullivan, Anthony Marfat, John B. Cheng, Theodore E. Liston, John W. Watson, J.S. Pillar, David B. Damon, J.T. Shirley, R. J. Chambers, Gerard Antognoli, Brian S. Owens
Rok vydání:	1998
Předmět:	Indoles Leukotriene D4 Stereochemistry Guinea Pigs Clinical Biochemistry Phenylcarbamates Pharmaceutical Science Biochemistry Chemical synthesis Tosyl Compounds chemistry.chemical_compound Drug Discovery medicine Animals Humans Potency Zafirlukast Imide Receptor Molecular Biology Receptors Leukotriene Indole test Sulfonamides Chemistry Organic Chemistry Antagonist Membrane Proteins Haplorhini respiratory system Rats Models Chemical Leukotriene Antagonists Molecular Medicine lipids (amino acids peptides and proteins) medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 8:2451-2456
ISSN:	0960-894X
Popis:	Exploration of the indole nitrogen region of Zafirlukast (1) has uncovered a potent series of cysteinyl leukotriene D4 (LTD4) antagonists. These studies showed that a variety of functionality could be incorporated in this region of the molecule without sacrificing potency. Efforts to exploit this site in order to improve oral efficacy are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ca40ed0f31d3457b3dd5a3ad8f6482 https://doi.org/10.1016/s0960-894x(98)00442-9 Zobrazit plný text záznamu Full Text from ScienceDirect