Critical Defect Healing Assessment in Rat Calvaria Filled with Injectable Calcium Phosphate Cement
| Autor: | Paulo Sérgio Perri de Carvalho, Pier Paolo Poli, Fabrizio Signorino, Francisley Ávila Souza, Rodrigo Capalbo da Silva, Carlo Maiorana, Luara Teixeira Colombo, Henrique Hadad, Ana Flávia Piquera Santos, Lara Cristina Cunha Cervantes, Igor Rodrigues de Vasconcelos, Luis Eduardo Schmidt |
|---|---|
| Přispěvatelé: | São Leopoldo Mandic School of Dentistry and Research Center, Universidade Estadual Paulista (Unesp), University of Milan |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
lcsh:Biotechnology Biomedical Engineering Dentistry Calvaria Bone healing Bone tissue Article Biomaterials chemistry.chemical_compound Tissue engineering lcsh:TP248.13-248.65 medicine Cement lcsh:R5-920 Bone decalcification business.industry biomaterial Biomaterial calcium phosphate cement Phosphate medicine.anatomical_structure chemistry bone healing business lcsh:Medicine (General) Calcium phosphate cement |
| Zdroj: | Journal of Functional Biomaterials Volume 10 Issue 2 Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of Functional Biomaterials, Vol 10, Iss 2, p 21 (2019) |
| ISSN: | 2079-4983 |
| DOI: | 10.3390/jfb10020021 |
| Popis: | (1) Background: The tissue engineering field has been working to find biomaterials that mimic the biological properties of autogenous bone grafts. (2) Aim: To evaluate the osteoconduction potential of injectable calcium phosphate cement implanted in critical defects in rat calvaria. (3) Methods: In the calvarial bone of 36 rats, 7-mm diameter critical size defects were performed. Afterwards, the animals were randomly divided into three groups according to filler material: a blood clot group (BC), blood clot membrane group (BCM), and an injectable &beta tricalcium phosphate group (HBS) cement group. After periods of 30 and 60 days, the animals were euthanized, the calvaria was isolated, and submitted to a decalcification process for later blades confection. Qualitative and quantitative analysis of the neoformed bone tissue were conducted, and histometric data were statistically analyzed. (4) Results: Sixty days post-surgery, the percentages of neoformed bone were 10.67 ± 5.57 in group BC, 16.71 ± 5.0 in group BCM, and 55.11 ± 13.20 in group HBS. The bone formation values in group HBS were significantly higher (p < 0.05) than in groups BC and BCM. (5) Conclusions: Based on these results, it can be concluded that injectable calcium phosphate cement is an osteoconductive material that can be used to fill bone cavities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|