Follow-up after 5.5 years of treatment with methylphenidate for mental fatigue and cognitive function after a mild traumatic brain injury
| Autor: | Lars Rönnbäck, Paulin Andréll, Birgitta Johansson, Clas Mannheimer |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
030506 rehabilitation
medicine.medical_specialty Traumatic brain injury medicine.medical_treatment Mental fatigue Neuroscience (miscellaneous) 03 medical and health sciences 0302 clinical medicine Cognition Brain Injuries Traumatic Developmental and Educational Psychology medicine Humans Depression (differential diagnoses) Brain Concussion Rehabilitation Cognitive Symptoms business.industry Methylphenidate medicine.disease Mental Fatigue Physical therapy Anxiety Central Nervous System Stimulants Neurology (clinical) medicine.symptom 0305 other medical science business 030217 neurology & neurosurgery medicine.drug Follow-Up Studies |
| Zdroj: | Brain injury. 34(2) |
| ISSN: | 1362-301X |
| Popis: | Objective: Prolonged mental fatigue and cognitive impairments are common after a mild traumatic brain injury (TBI). This sets limits for rehabilitation and for regaining the capacity for work and participation in social life.Method: This follow-up study, over a period of approximately 5.5 years was designed to evaluate the effect and safety of methylphenidate treatment for mental fatigue after a mild TBI. A comparison was made between those who had continued, and those who had discontinued the treatment. The effect was also evaluated after a four-week treatment break.Results: Significant improvement in mental fatigue, depression, and anxiety for the group treated with methylphenidate (p < .001) was found, while no significant change was found for the group without methylphenidate. The methylphenidate treatment group also improved their processing speed (p = .008). Withdrawal produced a pronounced and significant deterioration in mental fatigue, depression, and anxiety and a slower processing speed. This indicates that the methylphenidate effect is reversible if discontinued and that continued methylphenidate treatment can be a prerequisite for long-term improvement. The effect was found to be stable and safe over the years.Conclusion: We suggest methylphenidate to be a possible treatment option for patients with post-TBI symptoms including mental fatigue and cognitive symptoms. |
| Databáze: | OpenAIRE |
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