Local anesthetic effect of tramadol, metoclopramide, and lidocaine following intradermal injection
| Autor: | Wei-Wu Pang, Min-Ho Huang, Da-Peng Chang, Martin S. Mok |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Injections Intradermal Lidocaine Metoclopramide medicine.drug_class Analgesic Sensation Pain Placebos Double-Blind Method Humans Medicine Antiemetic Local anesthesia Intradermal injection Anesthetics Local Tramadol Pain Measurement Skin business.industry Local anesthetic General Medicine Middle Aged Surgery Analgesics Opioid Cold Temperature Anesthesiology and Pain Medicine Touch Anesthesia Antiemetics Female business Anesthesia Local medicine.drug |
| Zdroj: | Regional Anesthesia and Pain Medicine. 23:580-583 |
| ISSN: | 1098-7339 |
| DOI: | 10.1016/s1098-7339(98)90085-2 |
| Popis: | We observed clinically that tramadol and metoclopramide appear to have local anesthetic action. Tramadol is a central-acting analgesic. Metoclopramide is a commonly used antiemetic. The local anesthetic effect of tramadol in reducing propofol injection pain has never been mentioned, although it was speculated with metoclopramide.We conducted a double-blind, placebo-controlled study by injecting tramadol or metoclopramide intradermally in 10 healthy volunteers (5 men, 5 women; age 25-56 years). Each subject received 0.5 mL of four solutions in random order on the volar side of the forearm. These solutions were 25 mg tramadol, 5 mg metoclopramide, 5 mg lidocaine, and 0.5 mL normal saline. Pain on injections and the degree of local anesthesia (tested by pinprick, light touch, and cold) at each site was reported on a 0-3 scale at designed time intervals.Like 1% lidocaine, tramadol and metoclopramide demonstrated loss of sensation for pinprick, light touch, and cold for 15 minutes after intradermal injection (P.01 ).Intradermal tramadol or metoclopramide can produce local anesthetic effect. |
| Databáze: | OpenAIRE |
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