EFFECT OF POTASSIUM CHANNEL OPERATORS ON THE FIRING RATE OF HIPOCAMPAL PYRAMIDAL CELLS AND A10 DOPAMINERGIC NEURONSin vitro
| Autor: | de Tullio P, Vrijens B, Jacques Delarge, Laurent Massotte, Bernard Pirotte, Jacqueline Scuvée-Moreau, Seutin, Adelin Albert, Albert Dresse |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Cromakalim Potassium Channels Pyridines Physiology Dopamine Action Potentials Hippocampus In Vitro Techniques Biology Hippocampal formation Pharmacology Guanidines chemistry.chemical_compound Physiology (medical) medicine Diazoxide Animals Rats Wistar Neurons Thiadiazines Pinacidil Pyramidal Cells Ventral Tegmental Area Dopaminergic General Medicine Potassium channel Rats Electrophysiology nervous system chemistry medicine.drug |
| Zdroj: | Archives of Physiology and Biochemistry. 105:421-428 |
| ISSN: | 1744-4160 1381-3455 |
| DOI: | 10.1076/apab.105.5.421.3285 |
| Popis: | The effect of four KATP channel openers (KCOs) on the firing rate of CA1 pyramidal cells and A10 dopaminergic neurons was investigated using extracellular recording techniques in rat brain slices. Pinacidil, lemakalim, diazoxide and a new compound, BPDZ44, had an inhibitory effect on the electrical activity of CA1 pyramidal cells. They all had a similar potency. Only BPDZ44 and diazoxide inhibited the firing rate of A10 dopamine neurons. The sulfonylurea glipizide (1 microM) antagonized the effect of BPDZ44 and diazoxide on A10 neurons but failed to antagonize the effect of KCOs on CA1 pyramidal cells. These results show that differences exist among KCOs in their ability to decrease the electrical activity of various populations of central neurons. |
| Databáze: | OpenAIRE |
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