Synthesis of a B Ring Opened 7,8-seco-Vitamin B12 Derivative with Grob Fragmentation

Autor:	Bernhard Spingler, Lucas Prieto, René M. Oetterli, Felix Zelder
Rok vydání:	2013
Předmět:	Grob fragmentation Molecular Structure Stereochemistry Organic Chemistry Stereoisomerism Ring (chemistry) Biochemistry Cobalamin Vitamin B 12 Hydrolysis chemistry.chemical_compound chemistry Vitamin B12 Physical and Theoretical Chemistry Derivative (chemistry)
Zdroj:	Organic Letters. 15:4630-4633
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol401572j
Popis:	A synthetic route toward B ring opened 7,8-seco-cyanocobalamins is described. Hydrolysis of a novel c-lactone vitamin B12 (B12) derivative generates a cobalamin (Cbl) with a β-bromo alcoholate subunit that reacts in situ via Grob fragmentation to the secocorrin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c5eac86d7f2d95ea695765f98f2c7c https://doi.org/10.1021/ol401572j Zobrazit plný text záznamu