Harnessing epigenetics to study human evolution
| Autor: | Yoav Mathov, Liran Carmel, Daniel Batyrev, Eran Meshorer |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Neanderthal biology Genome Human Genetic Variation Archaic humans DNA Methylation biology.organism_classification Genome Epigenesis Genetic Evolution Molecular 03 medical and health sciences 0302 clinical medicine Ancient DNA Human evolution Evolutionary biology biology.animal DNA methylation Genetics Humans Epigenetics Denisovan 030217 neurology & neurosurgery 030304 developmental biology Developmental Biology |
| Zdroj: | Current opinion in geneticsdevelopment. 62 |
| ISSN: | 1879-0380 |
| Popis: | Recent advances in ancient DNA extraction and high-throughput sequencing technologies enabled the high-quality sequencing of archaic genomes, including the Neanderthal and the Denisovan. While comparisons with modern humans revealed both archaic-specific and human-specific sequence changes, in the absence of gene expression information, understanding the functional implications of such genetic variations remains a major challenge. To study gene regulation in archaic humans, epigenetic research comes to our aid. DNA methylation, which is highly correlated with transcription, can be directly measured in modern samples, as well as reconstructed in ancient samples. This puts DNA methylation as a natural basis for comparative epigenetics between modern humans, archaic humans and nonhuman primates. |
| Databáze: | OpenAIRE |
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