Telomere DNA Content in Prostate Biopsies Predicts Early Rise in Prostate-specific Antigen After Radical Prostatectomy for Prostate Cancer
| Autor: | Anthony Y. Smith, Larry Massie, Michael Davis, Jeffrey Griffith, Christopher M. Heaphy, Eric Treat, Marco Bisoffi |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Pathology Time Factors Prostate biopsy Urology medicine.medical_treatment urologic and male genital diseases Article Prostate cancer Predictive Value of Tests Prostate Biopsy Humans Medicine Aged Retrospective Studies Prostatectomy medicine.diagnostic_test business.industry Prostatic Neoplasms Cancer Retrospective cohort study DNA Middle Aged Prostate-Specific Antigen Telomere medicine.disease Prostate-specific antigen medicine.anatomical_structure Neoplasm Recurrence Local business |
| Zdroj: | Urology. 75:724-729 |
| ISSN: | 0090-4295 |
| DOI: | 10.1016/j.urology.2009.04.032 |
| Popis: | To determine whether measurement of telomere DNA content (TC) in prostate biopsy tissue predicts prostate-specific antigen (PSA) recurrence in men after undergoing radical prostatectomy for prostate cancer.Slot blot titration assay was used to quantitate TC in archived diagnostic prostate needle biopsy specimens for subjects (n = 103) diagnosed with prostate cancer and who subsequently underwent radical prostatectomy between 1993 and 1997. TC was compared to the clinical outcome measure; PSA recurrence, defined as an increase in PSAor = 0.2 ng/mL on 2 or more consecutive measurements post-prostatectomy, was observed retrospectively, for a mean follow-up period of 114 months (range, 1-165).In the cohort, 46 subjects had a PSA recurrence. In a univariate Cox proportional hazards model, low TC (0.3 of standard) demonstrated a significant risk for PSA recurrence (HR = 1.94; 95% CI: 1.02-3.69, P = .04). In a subset analysis of men with biopsy Gleason sumor = 6 (n = 63; 25 recurrences), a univariate Cox proportional hazards model demonstrated that low TC had a greater risk of PSA recurrence (HR = 4.53; 95% CI: 2.00-10.2, P.01). In a multivariate Cox proportional hazards model, low TC was also significantly associated with PSA recurrence in this subset after controlling for preoperative PSA levels (HR = 6.62; 95% CI: 2.69-16.3, P.01).Low TC measured in prostate biopsy tissue predicts early likelihood of post-prostatectomy PSA recurrence in a retrospective analysis, and in men with biopsy Gleason sumor = 6 disease it is also independent of preoperative PSA level. |
| Databáze: | OpenAIRE |
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