Lack of Association of Bone Morphogenetic Protein 2 Gene Haplotypes with Bone Mineral Density, Bone Loss, or Risk of Fractures in Men
| Autor: | Cyrus Cooper, Elaine M. Dennison, Roger M. Francis, SP Tuck, J Vila, Sarabjit S. Mastana, S S Varanasi, HK Datta |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Gerontology
Bone mineral musculoskeletal diseases Candidate gene animal structures Article Subject business.industry Endocrinology Diabetes and Metabolism lcsh:R Haplotype Osteoporosis lcsh:Medicine Physiology Single-nucleotide polymorphism medicine.disease musculoskeletal system Bone morphogenetic protein 2 Endocrinology Cohort embryonic structures medicine SNP business Research Article |
| Zdroj: | Journal of Osteoporosis Journal of Osteoporosis, Vol 2011 (2011) |
| ISSN: | 2042-0064 2090-8059 |
| Popis: | Introduction. The association of bone morphogenetic protein 2 (BMP2) with BMD and risk of fracture was suggested by a recent linkage study, but subsequent studies have been contradictory. We report the results of a study of the relationship between BMP2 genotypes and BMD, annual change in BMD, and risk of fracture in male subjects.Materials and Methods. We tested three single-nucleotide polymorphisms (SNPs) across the BMP2 gene, including Ser37Ala SNP, in 342 Caucasian Englishmen, comprising 224 control and 118 osteoporotic subjects.Results. BMP2 SNP1 (Ser37Ala) genotypes were found to have similar low frequency in control subjects and men with osteoporosis. The major informative polymorphism, BMP2 SNP3 (Arg190Ser), showed no statistically significant association with weight, height, BMD, change in BMD at hip or lumbar spine, and risk of fracture.Conclusion. There were no genotypic or haplotypic effects of the BMP2 candidate gene on BMD, change in BMD, or fracture risk identified in this cohort. |
| Databáze: | OpenAIRE |
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