Exposure–response relationships for select cancer and non-cancer health outcomes in a cohort of US firefighters from San Francisco, Chicago and Philadelphia (1950–2009)
| Autor: | Travis L. Kubale, Matthew M. Dahm, Robert D. Daniels, Thomas Hales, James J. Beaumont, Kathleen M. Waters, Dalsu Baris, James H. Yiin, Shelia Hoar Zahm, Lynne E. Pinkerton, Stephen J. Bertke |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Gerontology
Adult Male Lung Neoplasms Cumulative Exposure Risk Assessment Article Cohort Studies Age Distribution Cause of Death Occupational Exposure medicine Humans Aged Proportional Hazards Models Retrospective Studies Chicago Philadelphia Leukemia Proportional hazards model business.industry Incidence (epidemiology) Incidence Public Health Environmental and Occupational Health Cancer Retrospective cohort study Middle Aged medicine.disease Prognosis Survival Analysis Occupational Diseases Relative risk Firefighters Cohort San Francisco business Demography Cohort study |
| Popis: | Objectives To examine exposure–response relationships between surrogates of firefighting exposure and select outcomes among previously studied US career firefighters. Methods Eight cancer and four non-cancer outcomes were examined using conditional logistic regression. Incidence density sampling was used to match each case to 200 controls on attained age. Days accrued in firefighting assignments (exposed-days), run totals (fireruns) and run times (fire-hours) were used as exposure surrogates. HRs comparing 75th and 25th centiles of lagged cumulative exposures were calculated using loglinear, linear, log-quadratic, power and restricted cubic spline general relative risk models. Piecewise constant models were used to examine risk differences by time since exposure, age at exposure and calendar period. Results Among 19 309 male firefighters eligible for the study, there were 1333 cancer deaths and 2609 cancer incidence cases. Significant positive associations between fire-hours and lung cancer mortality and incidence were evident. A similar relation between leukaemia mortality and fire-runs was also found. The lung cancer associations were nearly linear in cumulative exposure, while the association with leukaemia mortality was attenuated at higher exposure levels and greater for recent exposures. Significant negative associations were evident for the exposure surrogates and colorectal and prostate cancers, suggesting a healthy worker survivor effect possibly enhanced by medical screening. Conclusions Lung cancer and leukaemia mortality risks were modestly increasing with firefighter exposures. These findings add to evidence of a causal association between firefighting and cancer. Nevertheless, small effects merit cautious interpretation. We plan to continue to follow the occurrence of disease and injury in this cohort. |
| Databáze: | OpenAIRE |
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