Shared preventive factors associated with relapse after a response to electroconvulsive therapy in four major psychiatric disorders

Autor:	Wataru Omori, Mami Okada-Tsuchioka, Yasumasa Okamoto, Naoto Kajitani, Hiromi Abe, Minoru Takebayashi, Kei Itagaki
Rok vydání:	2019
Předmět:	Male medicine.medical_specialty maintenance electroconvulsive therapy Multivariate analysis Lithium (medication) medicine.medical_treatment Schizoaffective disorder behavioral disciplines and activities electroconvulsive therapy 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy Recurrence mental disorders Humans Medicine Psychiatry Depression (differential diagnoses) Aged Retrospective Studies Univariate analysis business.industry Mental Disorders General Neuroscience Regular Article General Medicine Middle Aged Protective Factors medicine.disease 030227 psychiatry Psychiatry and Mental health Mood Neurology lithium Schizophrenia valproate preventive measures Female Neurology (clinical) business 030217 neurology & neurosurgery Regular Articles medicine.drug
Zdroj:	Psychiatry and Clinical Neurosciences
ISSN:	1440-1819 1323-1316
Popis:	Aim The efficacy of electroconvulsive therapy (ECT) has been established in psychiatric disorders but the high rate of relapse is a critical problem. The current study sought preventative factors associated with relapse after a response to ECT in a continuum of four major psychiatric disorders. Methods The records of 255 patients with four psychiatric disorders (83 unipolar depression, 60 bipolar depression, 91 schizophrenia, 21 schizoaffective disorder) were retrospectively reviewed. Results The relapse-free rate of all patients at 1 year was 56.3% in the four psychiatric disorders without a difference. As a result of univariate analysis, three items could be considered as preventative factors associated with relapse: a small number of psychiatric symptom episodes before an acute course of ECT, the use of mood stabilizers, and the use of maintenance ECT. Multivariate analysis was performed, keeping age, sex, and diagnosis constant in addition to the three items, and small number of psychiatric symptom episodes before an acute course of ECT (P = 0.003), the use of lithium (P = 0.025), the use of valproate (P = 0.027), and the use of maintenance ECT (P = 0.001) were found to be significant preventative measures against relapse. Conclusion The use of mood stabilizers, such as lithium and valproate, and maintenance ECT could be shared preventive factors associated with relapse after a response to ECT in four major psychiatric disorders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c183b50aa6ce8b43ff94198e643e9c https://doi.org/10.1111/pcn.12859 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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