Presurgical Assessment of the Sensorimotor Cortex Using Resting-State fMRI
| Autor: | M. Pailler, Fabien Schneider, J. Guyotat, François Vassal, Fabrice-Guy Barral, Claire Boutet, I. Faillenot |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Motor Activity EEG-fMRI Sensitivity and Specificity behavioral disciplines and activities Brain mapping 030218 nuclear medicine & medical imaging Task (project management) 03 medical and health sciences 0302 clinical medicine Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Child Stroke Sensorimotor cortex Aged Brain Mapping Functional medicine.diagnostic_test Resting state fMRI Brain Neoplasms business.industry Magnetic resonance imaging Glioma Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Female Sensorimotor Cortex Neurology (clinical) business Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | AJNR Am J Neuroradiol |
| ISSN: | 1936-959X 0195-6108 |
| DOI: | 10.3174/ajnr.a4472 |
| Popis: | BACKGROUND AND PURPOSE: The functional characterization of the motor cortex is an important issue in the presurgical evaluation of brain lesions. fMRI noninvasively identifies motor areas while patients are asked to move different body parts. This task-based approach has some drawbacks in clinical settings: long scanning times and exclusion of patients with severe functional or neurologic disabilities and children. Resting-state fMRI can avoid these difficulties because patients do not perform any goal-directed tasks. MATERIALS AND METHODS: Nineteen patients with diverse brain pathologies were prospectively evaluated by using task-based and resting-state fMRI to localize sensorimotor function. Independent component analyses were performed to generate spatial independent components reflecting functional brain networks or noise. Three radiologists identified the motor components and 3 portions of the motor cortex corresponding to the hand, foot, and face representations. Selected motor independent components were compared with task-based fMRI activation maps resulting from movements of the corresponding body parts. RESULTS: The motor cortex was successfully and consistently identified by using resting-state fMRI by the 3 radiologists for all patients. When they subdivided the motor cortex into 3 segments, the sensitivities of resting-state and task-based fMRI were comparable. Moreover, we report a good spatial correspondence with the task-based fMRI activity estimates. CONCLUSIONS: Resting-state fMRI can reliably image sensorimotor function in a clinical preoperative routine. It is a promising opportunity for presurgical localization of sensorimotor function and has the potential to benefit a large number of patients affected by a wide range of pathologies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|