Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing
| Autor: | Cristiano Frota de Souza Laurino, Márcia Bento Moreira, Karen Ruggeri Saad, Oronzo Pircchio, Paulo Fernandes Saad, Rogerio Fagundes Neves, Ricardo Simoes, Paulo Cesar Fagundes Neves, Simone de Campos Vieira Abib |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment H&E stain Bone healing Osteotomy Fractures Bone Hyperbaric oxygen medicine Combined Modality Therapy Animals Autologous platelet Fibula Platelet-rich Plasma Fracture Healing Hyperbaric Oxygenation lcsh:R5-920 business.industry Reproducibility of Results General Medicine Surgery Disease Models Animal Treatment Outcome Basic Research Platelet-rich plasma Fibula Fracture Consolidation Collagen Rabbits business lcsh:Medicine (General) |
| Zdroj: | Clinics, Vol 68, Iss 9, Pp 1239-1246 (2013) Clinics, Volume: 68, Issue: 9, Pages: 1239-1246, Published: SEP 2013 Clinics; v. 68 n. 9 (2013); 1239-1246 Clinics; Vol. 68 Núm. 9 (2013); 1239-1246 Clinics; Vol. 68 No. 9 (2013); 1239-1246 Clinics Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVES: The purpose is to study the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing the fibula bone of rabbits after induced fractures. METHODS: A total of 128 male New Zealand albino rabbits, between 6-8 months old, were subjected to a total osteotomy of the proximal portion of the right fibula. After surgery, the animals were divided into four groups (n = 32 each): control group, in which animals were subjected to osteotomy; autologous platelet concentrate group, in which animals were subjected to osteotomy and autologous platelet concentrate applied at the fracture site; hyperbaric oxygen group, in which animals were subjected to osteotomy and 9 consecutive daily hyperbaric oxygen therapy sessions; and autologous platelet concentrate and hyperbaric oxygen group, in which animals were subjected to osteotomy, autologous platelet concentrate applied at the fracture site, and 9 consecutive daily hyperbaric oxygen therapy sessions. Each group was divided into 4 subgroups according to a pre-determined euthanasia time points: 2, 4, 6, and 8 weeks postoperative. After euthanasia at a specific time point, the fibula containing the osseous callus was prepared histologically and stained with hematoxylin and eosin or picrosirius red. RESULTS: Autologous platelet concentrates and hyperbaric oxygen therapy, applied together or separately, increased the rate of bone healing compared with the control group. CONCLUSION: Hyperbaric oxygen therapy and autologous platelet concentrate combined increased the rate of bone healing in this experimental model. |
| Databáze: | OpenAIRE |
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