A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens
| Autor: | William J. Berglind, Peter W. Kalivas, Ryan T. LaLumiere, Jacqueline F. McGinty, Timothy W. Whitfield |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Glutamic Acid Prefrontal Cortex Self Administration Nucleus accumbens Synaptic Transmission Nucleus Accumbens Article Extinction Psychological Rats Sprague-Dawley Glutamatergic Cocaine-Related Disorders Cocaine Neurotrophic factors Animals Prefrontal cortex Brain-derived neurotrophic factor Chemistry General Neuroscience Brain-Derived Neurotrophic Factor Glutamate receptor Glutamic acid Rats nervous system Conditioning Operant Self-administration Extracellular Space Neuroscience |
| Zdroj: | The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(12) |
| ISSN: | 1529-2401 |
| Popis: | The glutamatergic pathway arising in the dorsomedial prefrontal cortex (dmPFC) and projecting to the nucleus accumbens (NAc) core is a critical component of the reward circuitry that underlies reinstatement to cocaine-seeking behavior. Brain-derived neurotrophic factor (BDNF) is expressed by and modulates PFC–NAc neurons. BDNF infusion into the dmPFC attenuates reinstatement to cocaine-seeking behavior, as well as some cocaine-induced molecular adaptations within the NAc. In the present study, it is demonstrated that a single intra-dmPFC infusion of BDNF prevents cocaine self-administration-induced reduction in basal extracellular glutamate, as well as cocaine prime-induced increases in extracellular glutamate levels within the NAc. These data suggest that intra-PFC BDNF attenuates reinstatement to cocaine-seeking behavior by normalizing cocaine-induced neuroadaptations that alter glutamate neurotransmission within the NAc. |
| Databáze: | OpenAIRE |
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