Stable cognitive functioning with improved perceptual reasoning in children with dyskinetic cerebral palsy and other secondary dystonias after deep brain stimulation
| Autor: | Jean-Pierre Lin, Tamsin Owen, Dolapo Adegboye, Richard Selway, Hortensia Gimeno |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Deep brain stimulation Adolescent medicine.medical_treatment Deep Brain Stimulation Population Neuropsychological Tests behavioral disciplines and activities Cerebral palsy Cohort Studies Perceptual Disorders 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Cognition medicine Humans education Child Problem Solving Retrospective Studies Dystonia education.field_of_study Cerebral Palsy Neuropsychology Wechsler Scales Repeated measures design General Medicine medicine.disease nervous system diseases Childhood secondary dystonia 030104 developmental biology Treatment Outcome surgical procedures operative Dystonic Disorders Deep brain stimulation surgery Child Preschool Pediatrics Perinatology and Child Health Physical therapy Female Neurology (clinical) Psychology Cognition Disorders 030217 neurology & neurosurgery Dyskinetic cerebral palsy |
| Zdroj: | Owen, T, Adegboye, D, Gimeno, H, Selway, R & Lin, J-P 2016, ' Stable cognitive functioning with improved perceptual reasoning in children with dyskinetic cerebral palsy and other secondary dystonias after deep brain stimulation ', European Journal of Paediatric Neurology . https://doi.org/10.1016/j.ejpn.2016.10.003 |
| DOI: | 10.1016/j.ejpn.2016.10.003 |
| Popis: | BackgroundDystonia is characterised by involuntary movements (twisting, writhing and jerking) and postures. Secondary dystonias are described as a heterogeneous group of disorders with both exogenous and endogenous causes. There is a growing body of literature on the effects of deep brain stimulation (DBS) surgery on the motor function in childhood secondary dystonias, however research on cognitive function after DBS is scarce.MethodsCognitive function was measured in a cohort of 40 children with secondary dystonia following DBS surgery using a retrospective repeated measures design. Baseline pre-DBS neuropsychological measures were compared to scores obtained at least one year following DBS. Cognitive function was assessed using standardised measures of intellectual ability and memory.ResultsThere was no significant change in the assessed domains of cognitive function following DBS surgery. A significant improvement across the group was found on the Picture Completion subtest, measuring perceptual reasoning ability, following DBS.ConclusionCognition remained stable in children with secondary dystonia following DBS surgery, with some improvements noted in a domain of perceptual reasoning. Further research with a larger sample is necessary to further explore this, in particular to further subdivide this group to account for its heterogeneity. This preliminary data has potentially positive implications for the impact of DBS on cognitive functioning within the childhood secondary dystonia population. |
| Databáze: | OpenAIRE |
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