Expression profile of RhoGDI2 in lung cancers and role of RhoGDI2 in lung cancer metastasis
| Autor: | Ping He, Hui Li, Huiyan Niu, Can Xu |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Cancer Research Lung Neoplasms Biology medicine.disease_cause Metastasis rho Guanine Nucleotide Dissociation Inhibitor beta Cell Line Tumor medicine Humans rho-Specific Guanine Nucleotide Dissociation Inhibitors Metastasis suppressor Neoplasm Metastasis RNA Small Interfering Lung cancer Protein kinase B PI3K/AKT/mTOR pathway Aged Guanine Nucleotide Dissociation Inhibitors Neoplasm Staging Aged 80 and over Oncogene Gene Expression Profiling Tumor Suppressor Proteins Carcinoma Cancer General Medicine Middle Aged medicine.disease Gene Expression Regulation Neoplastic Oncology Gene Knockdown Techniques Immunology Cancer research Female Carcinogenesis |
| Zdroj: | Oncology Reports. 24 |
| ISSN: | 1791-2431 1021-335X |
| Popis: | Rho GDP dissociation inhibitors (RhoGDIs) are important regulators of the GTP hydrolase activity and biological functions of Rho GTPases. RhoGDI2 has been shown to be a metastasis suppressor in bladder cancer and several other cancers. However, the underlying mechanism, effector targets, and the cognate biological functions of RhoGDI2 are not fully understood. To investigate the possible role of RhoGDI2 in lung cancer tumorigenesis and metastasis, the expression pattern of RhoGDI2 in various lung cancer tissue samples and lung cancer-derived cell lines were profiled at both mRNA and protein levels. Furthermore, possible interplay between PI3K/Akt/mTOR pathway activation/inhibition and RhoGDI2 signalling is examined in lung cancer-related cell lines. Our results suggest that RhoGDI2 is likely to be involved in lung tumor malignancy and metastasis. |
| Databáze: | OpenAIRE |
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