Increased intestinal permeability in malnourished patients with liver cirrhosis
| Autor: | Sabine Buhner, Matthias Pirlich, Jörg-Dieter Schulzke, Kristina Norman, Herbert Lochs, Christine Smoliner, Luzia Valentini |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Liver Cirrhosis
Male Alcoholic liver disease medicine.medical_specialty Cirrhosis Medicine (miscellaneous) Urine Gastroenterology Severity of Illness Index Permeability Lactulose Intestinal mucosa Dietary Sucrose Liver Cirrhosis Alcoholic Internal medicine medicine Humans Mannitol Intestinal Mucosa Aged Nutrition and Dietetics Intestinal permeability business.industry Malnutrition Middle Aged medicine.disease Small intestine Gastrointestinal Tract medicine.anatomical_structure Nutrition Assessment Gastric Mucosa Organ Specificity Female Atrophy business medicine.drug |
| Zdroj: | European journal of clinical nutrition. 66(10) |
| ISSN: | 1476-5640 |
| Popis: | Malnutrition is a prominent feature in liver cirrhosis, with deleterious impact on clinical outcome. The objective of this study is to investigate whether malnutrition is associated with increased gastrointestinal permeability in liver cirrhosis reflected by altered urinary excretion of non-metabolizable sugar probes. Patients with advanced liver cirrhosis (Child Pugh Score B or C) were recruited. Nutritional status was determined according to the Subjective Global Assessment. Intestinal permeability was assessed by measuring the urinary excretion of orally administered, non-metabolized sugar probe molecules. The lactulose/mannitol ratio served as marker for intestinal permeability and reflects non-carrier-mediated transcellular and paracellular transport of the small intestine during the first 5 h. Sucrose recovery in urine within the first 5 h reflects gastroduodenal permeability; sucralose recovery in urine 5–26 h after consumption reflects colonic permeability. Sixty-four patients (56.7±10.8 years; 33% female) were included in the study. Twenty-one patients were considered well nourished according to the Subjective Global Assessment, 23 moderately nourished and 20 patients severely malnourished; 74% had alcoholic liver disease and 67% had cirrhosis stage Child C. Gastroduodenal and colonic permeability was significantly increased in patients with liver cirrhosis compared with 63 healthy controls (0.23±0.22 and 1.37±1.42% vs 0.14±0.10 and 0.41±0.72% in controls), but not different between well and malnourished subjects. Small intestinal permeability (lactulose/mannitol ratio) was increased in all patients (0.069±0.055%) and further increased in malnourished patients (0.048±0.031% vs 0.084±0.061%, P=0.004) due to decreased mannitol recovery only. Gastric, small intestinal and even colonic permeability was altogether increased in liver cirrhosis, and malnutrition was associated with further increased small intestinal permeability indicative of villous atrophy. |
| Databáze: | OpenAIRE |
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