Metastatic chest wall tumor suspected to be of lung origin by immunoreactivity for cytokeratin 7 and 20
| Autor: | Mina Takushima, Masafumi Hioki, Kiyoshi Koizumi, Kazuo Shimizu, Kunio Yanagimoto, Shuji Haraguchi |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Pathology Lung Neoplasms Keratin-20 Adenocarcinoma Cytokeratin Carcinoembryonic antigen Surgical oncology medicine Humans Thoracic Wall Lung biology business.industry Keratin-7 General Medicine Thoracic Neoplasms medicine.disease Immunohistochemistry Cardiac surgery medicine.anatomical_structure Cardiothoracic surgery biology.protein Keratins Neoplasms Unknown Primary Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Japanese Journal of Thoracic and Cardiovascular Surgery. 54:132-136 |
| ISSN: | 1863-6713 1344-4964 |
| DOI: | 10.1007/bf02744878 |
| Popis: | We report a rare case of unknown primary carcinoma. A 36-year-old man was admitted to the hospital because of a chest wall tumor. Serum carcinoembryonic antigen level was 160 ng/ml. The resected chest wall tumor was pathologically diagnosed as metastatic adenocarcinoma, showing positive immunoreactivity for cytokeratin 7 and negative immunoreactivity for cytokeratin 20, suggesting lung origin. Serum carcinoembryonic antigen level returned to normal limits. Twenty-one months later, a chest X-ray showed a nodular lesion in the left upper lobe and serum carcinoembryonic antigen level increased to 12.3 ng/ml. Left upper lobectomy was performed 23 months after chest wall resection. The resected tumor was pathologically diagnosed as primary lung adenocarcinoma, showing the same immunoreactivity as in the chest wall tumor. The combination of immunohistochemistry for cytokeratin 7 and 20 appeared to be a useful tool in determining the site of origin and helpful for premortem diagnosis of the origin of unknown primary carcinoma. |
| Databáze: | OpenAIRE |
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