Increased T-cell responses that control bovine leukemia virus proviral load in beef cattle under dietary vitamin A restriction for marbling
| Autor: | Toh-Ichi Hirata, Chihiro Ochiai, Sonoko Miyauchi, Hirokazu Hikono, Kenji Murakami, Toshihiro Ichijo, Keiichi Matsuda, Yuzuru Katagiri |
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| Rok vydání: | 2020 |
| Předmět: |
Vitamin
viruses animal diseases Marbled meat T cell T-Lymphocytes Immunology Biology Beef cattle Dietary vitamin chemistry.chemical_compound Proviruses Interferon Gene expression medicine Leukemia Virus Bovine Animals Vitamin A General Veterinary Bovine leukemia virus virus diseases Enzootic Bovine Leukosis biology.organism_classification Virology Diet Red Meat medicine.anatomical_structure chemistry Cattle medicine.drug |
| Zdroj: | Veterinary immunology and immunopathology. 239 |
| ISSN: | 1873-2534 |
| Popis: | Bovine leukemia virus (BLV) proviral load is controlled by T-cell responses, which require vitamin A (VA) derived from food. However, whether dietary VA restriction for marbling impairs the T-cell responses that control BLV proviral load in beef cattle is unknown. We assessed T-cell subsets, interferon (IFN)-γ gene expression, and BLV proviral load in naturally BLV-infected Japanese Black cattle that were fed a diet with decreased VA levels. We found that the percentage of CD4+ T cells increased over time during dietary VA restriction. In addition, BLV proviral load was negatively correlated with the percentage of CD4+ T cells and with the level of IFN-γ gene expression. These observations suggest that dietary VA restriction for marbling enhances T-cell responses that control BLV proviral load and thus does not promote leukemogenesis in fattening beef cattle. |
| Databáze: | OpenAIRE |
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