Photoreactivity of fluoroquinolones: nature of aryl cations generated in water

Autor:	Francisco Bosca, Sonia Soldevila
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	Aqueous medium Molecular Structure Chemistry Aryl Organic Chemistry Water Photochemistry Photochemical Processes Biochemistry chemistry.chemical_compound medicine Flash photolysis Lomefloxacin sense organs Singlet state Physical and Theoretical Chemistry medicine.drug Fluoroquinolones
Zdroj:	RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname
Popis:	The nature of stabilized aryl cations generated from photodehalogenations of fluoroquinolones in aqueous media has been studied by comparing the photophysical and photochemical behavior of lomefloxacin (LFX) and its N(40)-acetylated form (ALFX). Photoproduct studies, laser flash photolysis, and emission measurements have shown that this small peripheral modification produces important changes in the properties of the singlet aryl cations generated. Also, in basic medium, a new photodehalogenation pathway for 6,8-dihalogenated fluoroquinolones has been observed. Financial support from Spanish government (CTQ2010-19909) and the Generalitat Valenciana (PROMETEO program, ref 2008/090) is gratefully acknowledged.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b3935a01eab13f66c43649392101b8 https://hdl.handle.net/10251/33012 Zobrazit plný text záznamu