Initial Biphasic Fractional Anisotropy Response to Blast-Induced Mild Traumatic Brain Injury in a Mouse Model
| Autor: | Palamadai N. Venkatasubramanian, Joachim Spiess, Alice M. Wyrwicz, Juan C. Piña-Crespo, Paul H Rigby, Matthew Smith, Kiran Mathews, Josh Duckworth |
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| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Traumatic brain injury Explosions Corpus callosum 03 medical and health sciences Mice 0302 clinical medicine Blast Injuries Fractional anisotropy Medicine Animals Brain Concussion 030304 developmental biology 0303 health sciences business.industry Basic Local Alignment Search Tool Public Health Environmental and Occupational Health General Medicine medicine.disease Disease Models Animal Diffusion Tensor Imaging Shock (circulatory) Anisotropy Supplement Article medicine.symptom business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Military Medicine |
| ISSN: | 1930-613X |
| Popis: | Introduction Blast-induced mild traumatic brain injury was generated in a mouse model using a shock tube to investigate recovery and axonal injury from single blast. Methods A supersonic helium wave hit the head of anesthetized male young adult mice with a reflected pressure of 69 psi for 0.2 ms on Day 1. Subsequently, the mice were cardioperfused on Days 2, 5, or 12. The isolated brains were subjected to diffusion tensor imaging. Reduced fractional anisotropy (FA) indicated axonal injury. Results After single blast, FA showed a biphasic response in the corpus callosum with decrease on Days 2 and 12 and increase on Day 5. Conclusions Blast-induced mild traumatic brain injury in a mouse model follows a biphasic FA response within 12 days after a single blast similar to that reported for human subjects. |
| Databáze: | OpenAIRE |
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