Spectrum of Cardiac Manifestations in COVID-19
| Autor: | Yael Lichter, Philippe Taieb, Ariel Banai, Guy Baruch, Yaron Arbel, Ehud Rothschild, Yogev Peri, Yishay Szekely, Yan Topilsky, Amir Gal Oz, Ilan Merdler, Aviram Hochstadt |
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| Rok vydání: | 2020 |
| Předmět: |
Male
2019-20 coronavirus outbreak Heart Diseases Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pneumonia Viral 030204 cardiovascular system & hematology Betacoronavirus 03 medical and health sciences 0302 clinical medicine Original Research Articles Physiology (medical) Correspondence Pandemic Humans Medicine Prospective Studies 030212 general & internal medicine Pandemics Aged Aged 80 and over biology SARS-CoV-2 business.industry COVID-19 heart ventricles thromboembolism Middle Aged biology.organism_classification Virology Troponin Echocardiography ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female Coronavirus Infections Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circulationaha.120.047971 |
| Popis: | Supplemental Digital Content is available in the text. Background: Information on the cardiac manifestations of coronavirus disease 2019 (COVID-19) is scarce. We performed a systematic and comprehensive echocardiographic evaluation of consecutive patients hospitalized with COVID-19 infection. Methods: One hundred consecutive patients diagnosed with COVID-19 infection underwent complete echocardiographic evaluation within 24 hours of admission and were compared with reference values. Echocardiographic studies included left ventricular (LV) systolic and diastolic function and valve hemodynamics and right ventricular (RV) assessment, as well as lung ultrasound. A second examination was performed in case of clinical deterioration. Results: Thirty-two patients (32%) had a normal echocardiogram at baseline. The most common cardiac pathology was RV dilatation and dysfunction (observed in 39% of patients), followed by LV diastolic dysfunction (16%) and LV systolic dysfunction (10%). Patients with elevated troponin (20%) or worse clinical condition did not demonstrate any significant difference in LV systolic function compared with patients with normal troponin or better clinical condition, but they had worse RV function. Clinical deterioration occurred in 20% of patients. In these patients, the most common echocardiographic abnormality at follow-up was RV function deterioration (12 patients), followed by LV systolic and diastolic deterioration (in 5 patients). Femoral deep vein thrombosis was diagnosed in 5 of 12 patients with RV failure. Conclusions: In COVID-19 infection, LV systolic function is preserved in the majority of patients, but LV diastolic function and RV function are impaired. Elevated troponin and poorer clinical grade are associated with worse RV function. In patients presenting with clinical deterioration at follow-up, acute RV dysfunction, with or without deep vein thrombosis, is more common, but acute LV systolic dysfunction was noted in ≈20%. |
| Databáze: | OpenAIRE |
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