Production of Gastroesophageal Erosions and Ulcers (GEU) in Gnotobiotic Swine Monoinfected with Fermentative Commensal Bacteria and Fed High-carbohydrate Diet
| Autor: | Robert A. Argenzio, D. M. Rings, Steven Krakowka, Kathryn A. Eaton |
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| Rok vydání: | 1998 |
| Předmět: |
0301 basic medicine
Liquid diet Swine 040301 veterinary sciences Gastrospirillum Bacillus Esophageal Diseases Epithelium Microbiology 0403 veterinary science 03 medical and health sciences Helicobacter Lactobacillus Dietary Carbohydrates Gastric mucosa medicine Animals Germ-Free Life Stomach Ulcer Swine Diseases General Veterinary biology Inoculation Helicobacter heilmannii 04 agricultural and veterinary sciences Hydrogen-Ion Concentration biology.organism_classification Commensalism 030104 developmental biology medicine.anatomical_structure Gastric Mucosa Esophagogastric Junction Cell Division |
| Zdroj: | Veterinary Pathology. 35:274-282 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/030098589803500406 |
| Popis: | Erosions and gastroesophageal ulcers (GEU) were produced in the pars esophagea of young gnotobiotic swine fed a carbohydrate-enriched liquid diet and monoinfected with two different fermentative commensal bacteria, Lactobacillus and Bacillus sp. In contrast, piglets, fed a similar diet and inoculated with Gastrospirillum sp. ( Helicobacter heilmannii), a helicobacter species that colonizes the gastric mucosa, did not develop GEU. Experimental GEU likely develops secondary to epithelial damage mediated by microbial-origin acids whose production is potentiated by high dietary carbohydrate and parietal cell-origin hydrochloric acid. |
| Databáze: | OpenAIRE |
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