A comparative study on perinatal outcomes of red blood cell-alloimmunized pregnancies with anti-RhD in combination and anti-RhD alone in China
| Autor: | Miaoqiong Situ, Rujiang Zheng, Muxue Yu, Jiali Feng, Tonghui Tang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
China Erythrocytes Blood Transfusion Intrauterine 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Foetal anaemia Pregnancy medicine Humans Intrauterine transfusion Retrospective Studies business.industry Obstetrics Significant difference Retrospective cohort study Hematology General Medicine medicine.disease Red blood cell Fetal Diseases medicine.anatomical_structure Neonatal outcomes Combination group Female business 030215 immunology |
| Zdroj: | Vox sanguinisREFERENCES. 117(2) |
| ISSN: | 1423-0410 |
| Popis: | BACKGROUND AND OBJECTIVES The advent of intrauterine transfusion (IUT) has improved the survival of severe foetal anaemia. The aim of this study was to compare the perinatal outcomes of red blood cell (RBC)-alloimmunized pregnancies with anti-RhD in combination and anti-RhD alone in China. MATERIALS AND METHODS A retrospective study was conducted involving RBC-alloimmunized pregnancies with anti-RhD in combination and anti-RhD alone admitted to The First Affiliated Hospital, Sun Yat-sen University, between January 2007 and December 2019. Obstetric data and neonatal outcomes were compared. RESULTS A total of 165 alloimmunized pregnancies were identified, with 32 pregnancies in the anti-RhD-in-combination group (25 pregnancies with anti-RhD + anti-RhC and 7 pregnancies with anti-RhD + anti-RhE) and 133 pregnancies in the anti-RhD-alone group. The anti-RhD-in-combination group had significantly higher frequency of IUTs than the anti-RhD-alone group (59.4% [19/32] vs. 30.1% [40/133]; p |
| Databáze: | OpenAIRE |
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