Angiotensin-converting enzyme genotype and encephalopathy in Chernobyl cleanup workers
| Autor: | E. Rabinovich, E. G. Neronov, Hugh Montgomery, N. M. Usmanova, A. M. Nikiforov, V. B. Shun’kov, O. V. Tikhomirova, N. M. Slozina, V. I. Kazakov, S. S. Alexanin, A Kehoe, N. V. Makarova |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Genotype Encephalopathy Peptidyl-Dipeptidase A Gastroenterology Cohort Studies Random Allocation Internal medicine Renin–angiotensin system Genetic model medicine Humans Genetic Predisposition to Disease Genetic Testing Radiation Injuries Ace inhibition Genetic testing medicine.diagnostic_test biology business.industry Dementia Vascular Angiotensin-converting enzyme Middle Aged medicine.disease Endocrinology Neurology Chernobyl Nuclear Accident biology.protein Neurology (clinical) business Radioactive Hazard Release Cohort study |
| Zdroj: | European journal of neurology. 16(1) |
| ISSN: | 1468-1331 |
| Popis: | To identify, using a genetic model, a key role for the renin-angiotensin system (RAS) in the development of dyscirculatory encephalopathy (DE) in Chernobyl cleanup workers (CCW). The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene denotes a substantial individual variation in RAS activity with the D-allele being associated with higher ACE activity.Ninety-three male, Caucasian CCW were recruited from those under regular review at the All-Russia Centre of Emergency and Radiation Medicine, St. Petersburg. The presence or absence of DE was determined using existing institutional guidelines. ACE genotype was determined using internationally accepted methodologies.Angiotensin-converting enzyme genotype distribution in 59 subjects with DE was II: 10 (17%), ID: 31 (53%), DD: 18 (30%), D-allele frequency 56.8%. Whereas in those without the condition the distribution was II: 12 (35%), ID: 19 (56%), DD 3 (9%) and D-allele frequency 35.9% (P = 0.02).These data are the first to identify an association between the ACE D-allele and DE in CCW. They provide evidence of a significant role for the RAS in the development of DE and suggest that clinical trials of ACE inhibition would be profitable in this group. |
| Databáze: | OpenAIRE |
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