The effects of different ventilatory modes in female adult rats submitted to mechanical ventilation
| Autor: | Thalles de Freitas Castro, Natália Alves de Matos, Ana Beatriz Farias de Souza, André Talvani, Frank Silva Bezerra, Guilherme de Paula Costa, Sílvia Dantas Cangussú, Jacques Gabriel Álvares Horta, Mônica Campos Andrade, Matheus Rocha Almeida, Leandro da Silva Cândido |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Respiratory rate Physiology medicine.medical_treatment Protein oxidation Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Parenchyma medicine Animals Rats Wistar Lung Tidal volume Mechanical ventilation Inflammation business.industry General Neuroscience Respiration Artificial Rats Disease Models Animal Oxidative Stress Endocrinology medicine.anatomical_structure 030228 respiratory system chemistry Breathing Cytokines Female business Bronchoalveolar Lavage Fluid 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Respiratory physiologyneurobiology. 284 |
| ISSN: | 1878-1519 |
| Popis: | This study aimed to analyze the effects of volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) modes in female Wistar rats. 18 Wistar female adult rats were divided into three groups: control (CG), pressure-controlled ventilation (PCVG), and volume-controlled ventilation (VCVG). PCVG and VCVG were submitted to MV for one hour with a tidal volume (TV) of 8 mL/Kg, respiratory rate of 80 breaths/min, and positive end-expiratory pressure of 0 cmH2O. At the end of the experiment, all animals were euthanized. The neutrophils and lymphocytes influx to lung were higher in VCVG and PCVG compared to CG. The activities of superoxide dismutase, catalase and myeloperoxidase were higher in PCVG compared to CG. There was an increase in lipid peroxidation and protein oxidation in PCVG compared to CG. The levels of CCL3 and CCL5 were higher in PCVG compared to CG. In conclusions, the PCV mode promoted structural changes in the lung parenchyma, redox imbalance and inflammation in healthy adult female rats submitted to MV. |
| Databáze: | OpenAIRE |
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