Probably anti-Tr associated paraneoplastic cerebellar degeneration as initial presentation of a squamous cell carcinoma of the lung
| Autor: | B. Appel, R. Crols, K. Bruylant, R.L. Humbel, P.P. De Deyn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
Cerebellum Pathology medicine.medical_specialty Lung Neoplasms Nerve Tissue Proteins Degeneration (medical) Paraneoplastic Cerebellar Degeneration Antibodies Mediastinoscopy Diagnosis Differential Bronchoscopy medicine Humans Pathological Aged Squamous-cell carcinoma of the lung medicine.diagnostic_test biology business.industry Brain General Medicine Paraneoplastic cerebellar degeneration medicine.disease Immunohistochemistry Magnetic Resonance Imaging medicine.anatomical_structure Epidermoid carcinoma biology.protein Carcinoma Squamous Cell Surgery Neurology (clinical) Antibody business |
| Zdroj: | Clinical neurology and neurosurgery |
| ISSN: | 0303-8467 |
| Popis: | Paraneoplastic cerebellar degeneration (PCD) is the most frequent paraneoplastic syndrome affecting the brain. Until now, anti-Tr associated PCD was only seen in patients with Hodgkin's disease. We report a male patient who presented with a progressive ataxia, affecting predominantly the lower limbs and a cerebellar dysarthria. Extensive diagnostic approach initially showed no evidence of tumor. The patient was found to have anti-Tr antibodies in his serum. Fourteen months after onset of symptoms a whole body PET-scan showed a pathological focus at the right hilus of the lungs. A mediastinoscopy was performed and peribronchial node sampling was done. The anatomopathological analysis revealed a non-well differentiated squamous cell carcinoma. This is the first report about the association between an anti-Tr associated PCD and squamous cell carcinoma. |
| Databáze: | OpenAIRE |
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