Antidepressant-like Effects of Medial Forebrain Bundle Deep Brain Stimulation in Rats are not Associated With Accumbens Dopamine Release
| Autor: | Roman Reznikov, Mustansir Diwan, Tatiana Bregman, Clement Hamani, José N. Nobrega, Roger Raymond, Christopher R. Butson |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Serotonin Deep brain stimulation medicine.medical_treatment Deep Brain Stimulation Dopamine Biophysics Stimulation Nucleus accumbens Nucleus Accumbens lcsh:RC321-571 Reward medicine Animals Medial forebrain bundle lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Early Growth Response Protein 1 business.industry Depression General Neuroscience Putamen Medial Forebrain Bundle Brain Immobility Response Tonic Antidepressive Agents Rats Ventral tegmental area medicine.anatomical_structure Brain stimulation reward Neurology (clinical) business Neuroscience medicine.drug |
| Zdroj: | Brain Stimulation, Vol 8, Iss 4, Pp 708-713 (2015) |
| ISSN: | 1876-4754 |
| Popis: | Background Medial forebrain bundle (MFB) deep brain stimulation (DBS) is currently being investigated in patients with treatment-resistant depression. Striking features of this therapy are the large number of patients who respond to treatment and the rapid nature of the antidepressant response. Objective To study antidepressant-like behavioral responses, changes in regional brain activity, and monoamine release in rats receiving MFB DBS. Methods Antidepressant-like effects of MFB stimulation at 100 μA, 90 μs and either 130 Hz or 20 Hz were characterized in the forced swim test (FST). Changes in the expression of the immediate early gene (IEG) zif268 were measured with in situ hybridization and used as an index of regional brain activity. Microdialysis was used to measure DBS-induced dopamine and serotonin release in the nucleus accumbens. Results Stimulation at parameters that approximated those used in clinical practice, but not at lower frequencies, induced a significant antidepressant-like response in the FST. In animals receiving MFB DBS at high frequency, increases in zif268 expression were observed in the piriform cortex, prelimbic cortex, nucleus accumbens shell, anterior regions of the caudate/putamen and the ventral tegmental area. These structures are involved in the neurocircuitry of reward and are also connected to other brain areas via the MFB. At settings used during behavioral tests, stimulation did not induce either dopamine or serotonin release in the nucleus accumbens. Conclusions These results suggest that MFB DBS induces an antidepressant-like effect in rats and recruits structures involved in the neurocircuitry of reward without affecting dopamine release in the nucleus accumbens. |
| Databáze: | OpenAIRE |
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