TREC/KREC Levels in Young COVID-19 Patients

Autor:	Sal'nikova Le, Daria A Sviridova, Artem Kuzovlev, Ekaterina V Kalinina, Maryam B. Khadzhieva, Sergey Sergeevich Larin, Ivan V Redkin, Julia Chursinova, Vadim Stepanov, Alesya S. Gracheva, Alexander G Rumyantsev, Lyudmila S. Avdeikina
Rok vydání:	2021
Předmět:	Medicine (General) ARDS medicine.medical_specialty Coronavirus disease 2019 (COVID-19) business.industry Communication Clinical Biochemistry Severe disease COVID-19 Acute respiratory distress acute respiratory distress syndrome TREC/KREC medicine.disease Systemic inflammation Gastroenterology Peripheral blood R5-920 neutrophil-to-lymphocyte ratio Internal medicine medicine IMMUNE IMBALANCE Neutrophil to lymphocyte ratio medicine.symptom business
Zdroj:	Diagnostics Diagnostics, Vol 11, Iss 1486, p 1486 (2021)
ISSN:	2075-4418
Popis:	COVID-19 patients with acute respiratory distress syndrome (ARDS) have an immune imbalance when systemic inflammation and dysfunction of circulating T and B cells lead to a more severe disease. Using TREC/KREC analysis, we studied the level of mature naive T and B cells in peripheral blood of COVID-19 patients and its relationship with clinical and laboratory data. TREC/KREC analysis was performed by multiplex real-time quantitative PCR on a sample of 36 patients aged 45 years or younger. The reduced TREC/KREC level was observed in ARDS patients compared with non-ARDS patients, and similar results were found for the deceased patients. During days 6 to 20 of hospitalization, a higher neutrophil-to-lymphocyte ratio (NLR) was detected in ARDS patients compared with non-ARDS patients. TREC/KREC negatively correlated with NLR; the highest correlation was recorded for TREC per 100,000 cells with the coefficient of determination R2 = 0.527. Thus, TREC/KREC analysis is a potential prognostic marker for assessing the severity and outcome in COVID-19.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a0cd1417903ba2fe4e9c1fb9ee2da5 https://pubmed.ncbi.nlm.nih.gov/34441420 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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