High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation

Autor: Vagner A. Benedito, Kaitlin Mock, Janet C. Tou, Sundus S. Lateef
Rok vydání: 2016
Předmět:
0301 basic medicine
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Biochemistry
Microsomal triglyceride transfer protein
Rats
Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
Non-alcoholic Fatty Liver Disease
Risk Factors
Internal medicine
Nonalcoholic fatty liver disease
medicine
Animals
PPAR alpha
Molecular Biology
Serum Albumin
Triglycerides
Dyslipidemias
Nutrition and Dietetics
biology
Triglyceride
High-fructose corn syrup
Cholesterol
HDL
Fructose
Alanine Transaminase
Cholesterol
LDL
gamma-Glutamyltransferase
medicine.disease
Lipid Metabolism
Rats
Fatty Acid Synthase
Type I
030104 developmental biology
Endocrinology
chemistry
Liver
Lipogenesis
Saturated fatty acid
biology.protein
Female
Stearoyl-CoA desaturase-1
High Fructose Corn Syrup
Stearoyl-CoA Desaturase
Zdroj: The Journal of nutritional biochemistry. 39
ISSN: 1873-4847
Popis: High-fructose corn syrup-55 (HFCS-55) has been suggested to be more lipogenic than sucrose, which increases the risk for nonalcoholic fatty liver disease (NAFLD) and dyslipidemia. The study objectives were to determine the effects of drinking different sugar-sweetened solutions on hepatic gene expression in relation to liver fatty acid composition and risk of NAFLD. Female rats were randomly assigned (n=7 rats/group) to drink water or water sweetened with 13% (w/v) HFCS-55, sucrose or fructose for 8 weeks. Rats drinking HFCS-55 solution had the highest (P=.03) hepatic total lipid and triglyceride content and histological evidence of fat infiltration. Rats drinking HFCS-55 solution had the highest hepatic de novo lipogenesis indicated by the up-regulation of stearoyl-CoA desaturase-1 and the highest (P
Databáze: OpenAIRE
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