Role of Apoptosis in disease
| Autor: | Nerino Allocati, Vincenzo Graziano, V De Laurenzi, Bartolo Favaloro, C Di Ilio |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Aging
Programmed cell death Heart Diseases Review Disease Bioinformatics Communicable Diseases Autoimmune Diseases diseases Neoplasms medicine Animals Humans cancer Caspase biology apoptosis Cancer Medical practice Cell Biology medicine.disease Clinical trial cell death caspases Apoptosis Immunology biology.protein Nervous System Diseases Signal transduction Signal Transduction |
| Zdroj: | Aging (Albany NY) Scopus-Elsevier |
| ISSN: | 1945-4589 |
| Popis: | Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling as well and shown that alterations of these pathways lead to human diseases. Indeed both reduced and increased apoptosis can result in pathology. More recently these findings have led to the development of therapeutic approaches based on regulation of apoptosis, some of which are in clinical trials or have entered medical practice. |
| Databáze: | OpenAIRE |
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