Co-infection of scrub typhus and leptospirosis in patients with pyrexia of unknown origin in Longding district of Arunachal Pradesh in 2013

Autor: Dipankar Biswas, Biswajyoti Borkakoty, Aniruddha Jakharia, Jagadish Mahanta
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Veterinary medicine
animal diseases
lcsh:QR1-502
Scrub typhus
lcsh:Microbiology
Disease Outbreaks
High morbidity
0302 clinical medicine
Immunology and Microbiology (miscellaneous)
Immunology and Allergy
leptospirosis
030212 general & internal medicine
Child
Aged
80 and over
Arunachal Pradesh
biology
integumentary system
Coinfection
Middle Aged
Leptospirosis
Antibodies
Bacterial
Infectious Diseases
Child
Preschool
Female
pyrexia of unknown origin
Microbiology (medical)
Adult
Adolescent
030231 tropical medicine
Immunology
India
Microbiology
Fever of Unknown Origin
03 medical and health sciences
Young Adult
co-infection
Leptospira
parasitic diseases
medicine
Humans
In patient
Aged
General Immunology and Microbiology
scrub typhus
business.industry
Infant
Newborn
Outbreak
Infant
medicine.disease
biology.organism_classification
bacterial infections and mycoses
Virology
Immunoglobulin M
bacteria
business
Malaria
Co infection
Zdroj: Indian Journal of Medical Microbiology, Vol 34, Iss 1, Pp 88-91 (2016)
ISSN: 1998-3646
0255-0857
Popis: Background: Scrub typhus and leptospirosis are bacterial zoonotic disease causing high morbidity and mortality. The seasonal outbreak of pyrexia is common in Arunachal Pradesh (AP); many times the disease remains undiagnosed. Objective: An outbreak of pyrexia of unknown origin (PUO) occurred in Longding district of Arunachal Pradesh in 2013, with 108 deaths, which was investigated to elucidate the cause of illness. Methodology: Blood samples from the affected region with acute pyrexia were collected, and screened for the malaria parasite, scrub typhus IgM and leptospira IgM. Results: Scrub typhus IgM was reactive in 97% (30/31), and 25% (8/31) cases were co-infected with leptospira. Incidentally, scrub typhus reactive (67%) and leptospira co-infection (62.7%) were higher in females. Record of previous 3 years (2011–2013) from Longding, Community Health Centre showed an increase in indoor pyrexia cases by 2-fold or more during October and November. Conclusion: The present study is the first report of co-infection of scrub typhus with leptospirosis from Northeast India. Medical officers in this region should take scrub typhus and leptospirosis in their differential diagnosis of patients with PUO for early diagnosis and effective treatment.
Databáze: OpenAIRE
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