Treatment preferences of adolescent patients with asthma
| Autor: | Ian Naya, Eugene Weinberg |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Indoles Randomization Adolescent Immunology Phenylcarbamates Administration Oral Tosyl Compounds Route of administration Surveys and Questionnaires medicine Humans Immunology and Allergy Anti-Asthmatic Agents Zafirlukast Child Asthma Sulfonamides Cross-Over Studies Inhalation business.industry Nebulizers and Vaporizers Inhaler Beclomethasone Beclometasone dipropionate medicine.disease Crossover study Patient Satisfaction Pediatrics Perinatology and Child Health Physical therapy Patient Compliance Female business Tablets medicine.drug |
| Zdroj: | Pediatric Allergy and Immunology. 11:49-55 |
| ISSN: | 1399-3038 0905-6157 |
| Popis: | The study objective was to assess whether asthmatic adolescents who were regular users of inhaled corticosteroids preferred treatment with zafirlukast tablets or inhaled beclomethasone dipropionate (BDP), and, secondarily, to assess adolescents' inhaler technique and their opinions about treatment. An open-label, randomized, two-period, crossover study was conducted in 18 centres (primary care to specialist asthma centres) in South Africa, the UK, Finland and the Czech Republic. One hundred and thirty-two adolescents aged 12-17 years with asthma for at least 1 year and FEV1 > or = 75% of predicted, treated with short-acting bronchodilators and inhaled corticosteroids, entered the study. Patients received oral zafirlukast tablets (Accolate) 20 mg b.i.d. or inhaled BDP 100 or 200 microg b.i.d., provided by a standard pressurized metered-dose inhaler, for 4 weeks each. One questionnaire was used to determine preference (the primary outcome measure) and a second questionnaire was used to determine patients' likes and dislikes of treatment. Investigators also scored inhaler technique. Of 113 adolescents, 79 (70%) preferred zafirlukast compared with 31 (27%) who preferred the BDP inhaler (p < 0.001); three had no preference. Only 35 (29%) of 122 adolescents could use their inhaler correctly at study entry. Seventy-six patients (65%) rated zafirlukast tablets as 'very easy' to use, compared with 35 (30%) for the BDP inhaler. Both treatments were well-tolerated. This study shows that asthmatic adolescents prefer zafirlukast tablets by a ratio of 2.6:1 over inhaled BDP, and these results may have implications for improving adolescent patient compliance with asthma therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|